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Wnt-C59

(Synonyms: C59)
37 Cited Publications
Customer Review

Based on 37 publication(s) in Google Scholar

Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.

For research use only. We do not sell to patients.

  • Purity: 99.88%
  • CAS No.: 1243243-89-1
  • Formula: C25H21N3O
  • Molecular Weight:379.45
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Wnt-C59 Chemical Structure
    Wnt-C59 Chemical Structure
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
  • Experimental Validation Results for Wnt-C59
CAS No.: 1243243-89-1
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Cell Proliferation/Viability Assay2D/3D Cell Culture and DifferentiationWBHistological Imaging/StainingRT-PCR
  • 2D/3D Cell Culture and Differentiation
  • Histological Imaging/Staining
  • Histological Imaging/Staining
  • WB
  • RT-PCR
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • WB

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  • Wnt-C59 Chemical Structure
    Wnt-C59 Chemical Structure
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  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Jan-Dec;15(1):2233149. [Abstract]

    Customer Validation
     Images of organoids that were treated with ileal contents from control and fucose-treated mice when there were Wnt signaling inhibitor Wnt-c59 (100 nM).

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Jan-Dec;15(1):2233149. [Abstract]

    Customer Validation
     Lgr5-EGFP staining of organoids that were treated with ileal contents from control and fucose-treated mice when there were Wnt signaling inhibitor Wnt-c59 (100 nM).

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: Gut Microbes. 2023 Jan-Dec;15(1):2233149. [Abstract]

    Customer Validation
     EdU staining of organoids that were treated with ileal contents from control and fucose-treated mice when there were Wnt signaling inhibitor Wnt-c59 (100 nM).

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2023 Apr 5;24(4):e54895. [Abstract]

    Customer Validation
     LAKTP murine tumor (MTO) cells were seeded in the indicated culture conditions and supplemented with LGK (10 μM) or WntC59 (100 nM). Total protein extracts were obtained and analyzed after 16 h of treatment.

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2023 Apr 5;24(4):e54895. [Abstract]

    Customer Validation
     LAKTP murine tumor (MTO) cells were seeded in the indicated culture conditions and supplemented with LGK (10 μM) or WntC59 (100 nM). Total RNA extracts were obtained and analyzed after 16 h of treatment.

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2023 Apr 5;24(4):e54895. [Abstract]

    Customer Validation
     Cell number was analyzed by CellTiter‐Go assay in MTO cells supplemented with WntC59 (100 nM) every 3 days (mean ± SD of three biological replicates).

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Jan 28;39(1):22. [Abstract]

    Customer Validation
     4 HCC PDOs were treated with a Notch signaling inhibitor (YO-01027), Wnt signaling inhibitor (Wnt-C59, 0-20 μM), Hippo signaling inhibitor (verteporfin), or Hedgehog signaling inhibitor (GANT61) for 6 days and cell viability was recorded.

  • 1/16

    Wnt-C59 purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(3):1251-1262. [Abstract]

    Customer Validation
     The protein levels of Wnt3a and β-catenin are examined in MCF-7 spheres and MDA-MB-231 spheres with Wnt-C59 treatment or not via western blot analysis.

  • Wnt-C59