EJMC-1
Based on 1 Customer Validation
EJMC-1 is a moderately potent TNF-α inhibitor with an IC50 value of 42 μM.
For research use only. We do not sell to patients.
- Purity: 98.08%
- CAS No.: 397281-20-8
- Formula: C17H11ClN2O4S
- Molecular Weight:374.80
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
42.3 μM
Compound: 1
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Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay system
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[PMID: 25078315] |
| HeLa | IC50 |
45.7 μM
Compound: 1
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Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
Inhibition of TNFalpha (unknown origin) assessed as IkappaB-alpha phosphorylation in Hela cells after 15 mins by ELISA
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[PMID: 25078315] |
Chemical Information
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CAS No. 397281-20-8
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Appearance Solid
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Molecular Weight 374.80
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Formula C17H11ClN2O4S
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Color Light yellow to yellow
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SMILES
O=C1NC2=CC=C(S(=O)(NC3=CC=C(C(Cl)=C3)O)=O)C4=C2C1=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (333.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6681 mL | 13.3404 mL | 26.6809 mL | 66.7022 mL |
| 5 mM | 0.5336 mL | 2.6681 mL | 5.3362 mL | 13.3404 mL | |
| 10 mM | 0.2668 mL | 1.3340 mL | 2.6681 mL | 6.6702 mL | |
| 15 mM | 0.1779 mL | 0.8894 mL | 1.7787 mL | 4.4468 mL | |
| 20 mM | 0.1334 mL | 0.6670 mL | 1.3340 mL | 3.3351 mL | |
| 25 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 30 mM | 0.0889 mL | 0.4447 mL | 0.8894 mL | 2.2234 mL | |
| 40 mM | 0.0667 mL | 0.3335 mL | 0.6670 mL | 1.6676 mL | |
| 50 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 60 mM | 0.0445 mL | 0.2223 mL | 0.4447 mL | 1.1117 mL | |
| 80 mM | 0.0334 mL | 0.1668 mL | 0.3335 mL | 0.8338 mL | |
| 100 mM | 0.0267 mL | 0.1334 mL | 0.2668 mL | 0.6670 mL |
EJMC-1 Related Classifications
HY-147078 Related Classifications
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