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Cat. No.: HY-112942

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CMP-Sialic acid

(Synonyms: CMP-Neu5Ac)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

For research use only. We do not sell to patients.

CAS No.: 3063-71-6
Formula: C₂₀H₃₁N₄O₁₆P
Molecular Weight:614.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

CMP-Sialic acid Chemical Structure

CAS No.: 3063-71-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

CMP-Sialic acid (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3063-71-6
Molecular Weight 614.45
Formula C₂₀H₃₁N₄O₁₆P
SMILES

O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O)=O
Synonyms

CMP-Neu5Ac
Structure Classification
- Others
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

All In Vivo Efficacy StudyELISA

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Adv Mater

Shutting Down the 'Language Encoder': A Pathogen-Derived Nano-Interferer Disrupt Sialylation Metabolism and Reprogram Intercellular Communication in Glioblastoma. [Abstract]

2025 Nov 29:e16608. PMID: 41316829
Cell Host Microbe

Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism. [Abstract]

2025 Jul 9;33(7):1133-1145.e4. PMID: 40494348

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε^−/− mice when administered intravaginally.

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε^−/− and anti-IFNAR-treated mice.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

CMP-Sialic acid

3 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (3)
Purity & Documentation
References

1/16
1/16

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Customer Validation
CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 d), the product of CMAS, enhanced gonococcal burden in C57BL/6 J WT and Ifnε^−/− mice when administered intravaginally.
1/16

CMP-Sialic acid purchased from MedChemExpress. Usage Cited in: Cell Host Microbe. 2025 Jul 9;33(7):1133-1145.e4. [Abstract]

Customer Validation
Intravaginal CMP-Neu5Ac (CMP-Sialic acid sodium salt; 25 μg; i.vag.; once daily for 8 days) instillation restored LOS sialylation in Ifnε^−/− and anti-IFNAR-treated mice.

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CMP-Sialic acid

Publications Citing Use of MedChemExpress (MCE) CMP-Sialic acid

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

CMP-Sialic acid Related Classifications

HY-112942 Related Classifications