Fustin
Based on 1 Customer Validation
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- Purity : 99.6%
- CAS No.: 20725-03-5
- Formula: C15H12O6
- Molecular Weight:288.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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AChE |
mAChR1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>100 μg/mL
Compound: 21
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Cytotoxicity in human K562 cells by SRB assay
Cytotoxicity in human K562 cells by SRB assay
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[PMID: 28793973] |
In Vivo
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Decreased freezing response in Aβ-treated C57BL/6 mice.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.
Chemical Information
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CAS No. 20725-03-5
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Appearance Solid
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Molecular Weight 288.26
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Formula C15H12O6
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Color White to off-white
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SMILES
OC1=CC([C@H]2OC3=CC(O)=CC=C3C([C@@H]2O)=O)=CC=C1O
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Synonyms
(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (346.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (296 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4691 mL | 17.3455 mL | 34.6909 mL | 86.7273 mL |
| 5 mM | 0.6938 mL | 3.4691 mL | 6.9382 mL | 17.3455 mL | |
| 10 mM | 0.3469 mL | 1.7345 mL | 3.4691 mL | 8.6727 mL | |
| 15 mM | 0.2313 mL | 1.1564 mL | 2.3127 mL | 5.7818 mL | |
| 20 mM | 0.1735 mL | 0.8673 mL | 1.7345 mL | 4.3364 mL | |
| 25 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4691 mL | |
| 30 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8909 mL | |
| 40 mM | 0.0867 mL | 0.4336 mL | 0.8673 mL | 2.1682 mL | |
| 50 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7345 mL | |
| 60 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 80 mM | 0.0434 mL | 0.2168 mL | 0.4336 mL | 1.0841 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL |
Fustin Related Classifications
HY-N8376 Related Classifications
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