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Pacibekitug

(Synonyms: PF-04236921; TOUR-006)
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Based on 1 Customer Validation

Pacibekitug (PF-04236921; TOUR-006) is a fully humanized IgG2 monoclonal antibody targeting IL-6. Pacibekitug binds to and neutralizes IL-6 signaling, thereby inhibiting the pathophysiological role of this pro-inflammatory cytokine in autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus)[1][2].

For research use only. We do not sell to patients.

  • Purity : 99.60%
  • CAS No.: 2948444-06-0
  • Molecular Weight:144.426 kDa
  • Storage:
    Shipping with dry ice

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Pacibekitug
  • Experimental Validation Results for Pacibekitug
  • Experimental Validation Results for Pacibekitug
  • Pacibekitug Chemical Structure
    Pacibekitug Chemical Structure
CAS No.: 2948444-06-0
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Pacibekitug Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Interleukin Related Isoforms

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Assay Types
  • 1/16

    IgG2-kappa

  • 1/16

    Immobilized IL-6 Protein, Human (HY-P7044) can bind Pacibekitug. The EC50 for this effect is 6.84 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 SiHa cells labeling IL-6 with Pacibekitug(HY-P990937, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Pacibekitug Chemical Structure
    1/16
  • Pacibekitug
  • Immobilized IL-6 Protein, Human (HY-P7044) can bind Pacibekitug. The EC50 for this effect is 6.84 ng/mL.
  • Flow cytometric analysis of 1X106 SiHa cells labeling IL-6 with Pacibekitug(HY-P990937, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 kappa Isotype Control (HY-P99002, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG2-kappa