IL-33
Interleukin-33 (IL-33) is a nuclear alarmin of the IL-1 family, constitutively stored in the chromatin of epithelial and endothelial barrier cells and released upon necrotic cell damage, mechanical injury or allergen exposure. Full-length IL-33 functions as a nuclear transcriptional repressor, whereas proteolytic processing by neutrophil elastase, cathepsin G or mast cell proteases yields a mature superactive cytokine. IL-33 binds the suppression of tumorigenicity 2 receptor (ST2/IL-1RL1), recruiting IL-1RAcP to activate MyD88-IRAK-NF-κB and MAPK signaling. It potently drives group 2 innate lymphoid cells, Th2 cells, mast cells, eosinophils and basophils, eliciting IL-4, IL-5, IL-13, IgE and type 2 inflammation in asthma, atopic dermatitis and food allergy. IL-33 also promotes regulatory T cell expansion in tissues and is implicated in cardiovascular and central nervous system inflammation.
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IL-33 Recombinant Proteins (14)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
