RS-56812
RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease).
For research use only. We do not sell to patients.
- CAS No.: 143137-35-3
- Formula: C18H21N3O2
- Molecular Weight:311.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All 5-HT Receptor Isoforms
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Biological Activity
Description
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5-HT3 Receptor |
Chemical Information
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CAS No. 143137-35-3
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Molecular Weight 311.38
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Formula C18H21N3O2
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SMILES
O=C(NC1CN2CCC1CC2)C(C3=CN(C)C4=C3C=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
[1]. Terry AV Jr, et al. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8(1):49-54. [Content Brief]
[2]. Boakye PA, et al. 5-HT(3) and 5-HT(4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterol Motil. 2012 Jan;24(1):e27-40. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RS-56812 Related Classifications
HY-135493 Related Classifications
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