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Cat. No.: HY-W040167

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VPC 23153

VPC 23153 is a S1P₄ receptor agonist and vasoconstrictor. VPC 23153 activates the S1P₄ receptor, thereby triggering vasoconstriction. VPC 23153 induces pulmonary artery contraction. VPC 23153 can be used in studies related to pulmonary arterial hypertension.

For research use only. We do not sell to patients.

CAS No.: 787582-98-3
Formula: C₁₇H₂₈N₃O₄P
Molecular Weight:369.40

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Please store the product under the recommended conditions in the Certificate of Analysis.

VPC 23153 Chemical Structure

CAS No.: 787582-98-3

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Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

IC₅₀ & Target^[1]

S1PR4

All LPL Receptor Isoforms :

In Vitro

VPC 23153 (0.01-3 μM) induces dose-dependent vasoconstriction in isolated perfused normotensive rat lungs^[1].
VPC 23153 (0.1-10 μM) induces concentration-dependent contraction of isolated pulmonary arteries (but not renal or mesenteric arteries) from chronically hypoxic rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 787582-98-3
Molecular Weight 369.40
Formula C₁₇H₂₈N₃O₄P
SMILES

[C@@H](COP(=O)(O)O)(N)C=1NC=2C(N1)=CC=C(CCCCCCCC)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ota H, et al. S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. Pulm Circ. 2011;1(3):399-404. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VPC 23153

All LPL Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VPC 23153 Related Classifications

HY-W040167 Related Classifications