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Cat. No.: HY-184949

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XY-06-005

XY-06-005 is a modified selective inhibitor of BET bromodomain that binds to BRD4 BD1 L94V, BRD4 BD2 L387V and BRD2 BD2 L383V. XY-06-005 serves as a Ligand for Target Protein for PROTAC for studies related to PROTAC synthesis, such as acting as the target protein ligand structure of XY-06-007 (HY-145226).

For research use only. We do not sell to patients.

CAS No.: 1642783-78-5
Formula: C₂₂H₂₁ClN₄O₃
Molecular Weight:424.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

XY-06-005 Chemical Structure

CAS No.: 1642783-78-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

BRD4 BD1

BRD4 BD2

BRD4 BD1L94V

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In Vitro

XY-06-005 (compound 3) potently binds to mutant bromodomains (BRD4 BD1 L94V, BRD4 BD2 L387V, BRD2 BD2 L383V) with IC₅₀ values ranging from 62 nM to 231 nM. In contrast, it shows significantly weaker binding affinity to wild-type BRD4 BD1 (39 nM) and BRD4 BD2 (863 nM), indicating its selectivity for mutant bromodomains over wild-type counterparts^[1].
XY-06-005 can serve as the target protein ligand structure of XY-06-007 (HY-145226). XY-06-007 is a potent and selective B&H-PROTAC BRD4 BD1 L94V degrader with a DC₅₀ of 10 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1642783-78-5
Molecular Weight 424.88
Formula C₂₂H₂₁ClN₄O₃
SMILES

ClC1=CC=C(C2=N[C@H](C3=NN=C(N3C4=C2C=C(C=C4)OC)C)[C@H](C(OC)=O)C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nowak RP, et al. Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. Journal of medicinal chemistry. 2021 Aug 12;64(15):11637-11650. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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XY-06-005

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

XY-06-005 Related Classifications

HY-184949 Related Classifications