YMU1
Based on 1 Customer Validation
YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 902589-96-2
- Formula: C17H22N4O4S
- Molecular Weight:378.45
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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STAT3 |
YMU1 (0.1-10 μM, 10 min) has no inhibitory effect on TK1[1].
YMU1 is not toxic to the genome and, similar to TMPK silencing, impaires DSB repair[1].
YMU1 (1-10 μM, 14 days) has little effect on cell growth in H184B5F5M10, MCF10A, MCF-7, and HCT-116 cells[1].
YMU1 does not inhibit dUTPase in vitro[1].
YMU1 sensitizes malignant tumor cells to doxorubicin in vitro[1].
YMU1 (3-10 μM, 72 h) inhibits A549 cell proliferation, migration, and invasion[2].
YMU1 (3-10 μM, 72 h) controls the activation of STAT3 signaling pathway in LUAD cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H184B5F5M10, MCF10A, MCF-7, HCT-116
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Concentration:1, 10 μM
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Incubation Time:14 days; twice a week
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Result:Had little effect on cell growth.
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Cell Line:A549
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Concentration:3, 10 μM
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Incubation Time:72 h
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Result:Decreased cell viability.
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Cell Line:A549
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Concentration:3, 10 μM
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Incubation Time:72 h
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Result:Inhibited cell migration.
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Cell Line:A549
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Concentration:3, 10 μM
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Incubation Time:72 h
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Result:Inhibited cell invasion.
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Cell Line:A549; LUAD
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Concentration:3, 10 μM
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Incubation Time:72 h
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Result:Increased E-Cadherin approximately 3-fold, reduced N-Cadherin, fibronectin, and vimentin by more than 50%, and significantly reduced pSTAT3 levels, while total STAT3 levels had no significant change.
YMU1 (3-10 mg/kg, intraperitoneal injection, once every two days, for 30 days) inhibits the growth of A549 xenograft tumors in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HCT-116 p53-/- cell transplantation model in nude mice[1]
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Dosage:5 mg/kg; 3 times a week; 25 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Showed that tumors grew significantly slower in mice treated with doxorubicin.
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Animal Model:A549 nude mouse transplantation model[2]
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Dosage:3,10 mg/kg; once every two days; 30 days
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Administration:Intraperitoneal injection (i.p.)
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Result:Reduced tumor volume and weight in a dose-dependent manner.
Chemical Information
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CAS No. 902589-96-2
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Appearance Solid
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Molecular Weight 378.45
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Formula C17H22N4O4S
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Color Off-white to light yellow
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SMILES
O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 5.56 mg/mL (14.69 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6424 mL | 13.2118 mL | 26.4236 mL | 66.0589 mL |
| 5 mM | 0.5285 mL | 2.6424 mL | 5.2847 mL | 13.2118 mL | |
| 10 mM | 0.2642 mL | 1.3212 mL | 2.6424 mL | 6.6059 mL |
YMU1 Related Classifications
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