JNJ-10258859
JNJ-10258859 is a potent and selective phosphodiesterase type 5 inhibitor, with a Ki of 0.23 nM. JNJ-10258859 can be used for erectile dysfunction research.
For research use only. We do not sell to patients.
- CAS No.: 374927-03-4
- Formula: C30H24N4O3
- Molecular Weight:488.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE5 0.23±0.03 nM (Ki) |
PDE4 5.01±1.88 μM (Ki) |
PDE3 9.67±1.95 μM (Ki) |
PDE2 25.33±5.53 μM (Ki) |
PDE1 >100 μM (Ki) |
JNJ-10258859 is efficacious in potentiating cGMP accumulation in RFL-6 cells, demonstrating its ability to penetration cell membrane[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 374927-03-4
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Molecular Weight 488.54
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Formula C30H24N4O3
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SMILES
O=C1C2=C(NC3=C1C=CC=C3)[C@H](N(C2)C4=NC=C(C=N4)C5=CC=C(C=C5)OC)C6=CC=C7OCCC7=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNJ-10258859 Related Classifications
HY-123145 Related Classifications
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