Iberin
Based on 2 publication(s) in Google Scholar
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 505-44-2
- Formula: C5H9NOS2
- Molecular Weight:163.26
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Storage:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Flavopiridol HydrochlorideCDK Inhibitor -
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Cilastatin-15N,d3Stable Isotope -
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SesamolApoptosis Inducer -
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Incensole AcetateApoptosis Modulator -
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(E)-Methyl 4-coumarateDerivative Of Cinnamic Acid -
HY-15449R
Kaempferide (Standard) -
HY-N2492R
(E)-Methyl 4-coumarate (Standard)Standard Of (E)-Methyl 4-coumarate
Publications Citing Use of MedChemExpress (MCE) Iberin
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
IC50: 2.3 μM (HL60 cell)[1]
In Vitro
Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP[2]. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 505-44-2
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Appearance Liquid
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Molecular Weight 163.26
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Formula C5H9NOS2
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Color Colorless to light yellow
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SMILES
O=S(CCCN=C=S)C
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Synonyms
NSC 321801
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Prod Res
Bioactivity-guided characterisation of iberin from Cakile edentula (Bigelow) Hook. inducing apoptosis in human melanoma cells. [Abstract]2025 Jun 5:1-7. PMID: 40470544 -
Biomed Pharmacother
Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression. [Abstract]2021 Oct:142:111533. PMID: 34148735
Purity & Documentation
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Data Sheet (272 KB)
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SDS (565 KB)
- English - EN (565 KB)
- Français - FR (565 KB)
- Deutsch - DE (565 KB)
- Norwegian - NO (565 KB)
- Español - ES (565 KB)
- Swedish - SV (565 KB)
- Italian - IT (565 KB)
- Korean - KR (565 KB)
- Portuguese - PT (565 KB)
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Handling Instructions (2659 KB)
References
[1]. Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3375-86. [Content Brief]
[2]. Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. [Content Brief]
[3]. Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103(2):247-51. [Content Brief]
[4]. Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. [Content Brief]
[5]. Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7):1867-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Iberin Related Classifications
HY-101413 Related Classifications
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