AMG-151
AMG-151 (ARRY-403) is a glucokinase agonist with fasting plasma glucose (FPG) lowering activity. AMG-151 showed a significant linear dose-response trend compared with placebo in a randomized, placebo-controlled Phase IIa study. The use of AMG-151 was associated with a higher incidence of hypoglycemia and hypertriglyceridemia. AMG-151 may serve as a potential compound for the inhibition of type 1 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 1138669-65-4
- Formula: C20H18N6O3S2
- Molecular Weight:454.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1138669-65-4
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Molecular Weight 454.53
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Formula C20H18N6O3S2
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SMILES
O[C@H](CO)C1=NSC(NC2=NC=C(C=C2OC3=CC=CN=C3C)SC4=NC=CC=C4)=N1
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Synonyms
ARRY-403
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMG-151 Related Classifications
HY-125316 Related Classifications
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