Cat. No.: HY-N7083

Citral

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

Citral is an orally active monoterpene compound in lemon grass essential oil and a natural ALDH1A inhibitor, which can induce apoptosis and cycle arrest in breast cancer cell lines, and has analgesic, anti-injurious and anti-inflammatory effects^[2][3].

For research use only. We do not sell to patients.

Purity: 99.81%
CAS No.: 5392-40-5
Formula: C₁₀H₁₆O
Molecular Weight:152.23

Storage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Citral Chemical Structure

CAS No.: 5392-40-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Aldehyde Dehydrogenase (ALDH) Isoforms :

In Vitro

Citral (10, 50, 100 μg/mL, 72 h) has no cytotoxicity to J774 macrophages^[1].
Citral (0-0.5 μM, 72 h) inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 breast cancer cell line^[2].
Citral (0-100 μg/mL, 72 h) exhibits anti-proliferative and pro-apoptotic activities in MDA-MB-231 breast cancer cell line^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1].

Cell Line:

J774 cell
Concentration:

10, 50, 100 μg/mL
Incubation Time:

72 h
Result:

Didn't affect the cell viability of J774 cells

Cell Proliferation Assay^[2].

Cell Line:

MCF-7 cell
Concentration:

0-0.5 μM
Incubation Time:

72 h
Result:

Inhibited the proliferation of MCF-7 cells

Cell Cytotoxicity Assay^[3].

Cell Line:

MDA-MB-231 cell
Concentration:

0-100 μg/mL
Incubation Time:

72 h
Result:

Inhibited the cell viability of MDA-MB-231 cells

In Vivo

Citral (100 mg/kg, p.o.) improves the anti-hyperalgesic and anti-inflammatory activities in pleurisy mice^[1].
Citral (10, 20, 40 mg/kg, i.p.) prevents LPS induced mouse endometritis by activating the Nrf2 signaling pathway and inhibiting ferroptosis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

pleurisy adult (2 to 3 months old) male Swiss mice^[1].
Dosage:

100 mg / kg body weight
Administration:

oral gavage (p.o.)
Result:

Reduced white blood cell count and TNF-α expression level ^[1].

Animal Model:

Female BALB/c mice^[4].
Dosage:

10, 20, 40 mg/kg body weight
Administration:

intraperitoneal injection (i.p.)
Result:

Attenuated uterine pathological damage, infammation, and ferroptosis^[4].

Chemical Information

CAS No. 5392-40-5
Appearance Liquid (Density: 0.888 g/cm³)
Molecular Weight 152.23
Formula C₁₀H₁₆O
Color Colorless to light yellow
SMILES

C/C(C)=C\CC/C(C)=C/C=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Bioeng Transl Med

An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis. [Abstract]

2021 Apr 2;6(3):e10219. PMID: 34589596

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (656.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.5690 mL

32.8450 mL

65.6901 mL

5 mM

1.3138 mL

6.5690 mL

13.1380 mL

10 mM

0.6569 mL

3.2845 mL

6.5690 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (16.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Campos CA, et al. Anti-hyperalgesic and anti-inflammatory effects of citral with β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes in animal models. Life Sci. 2019 Jul 15;229:139-148. [Content Brief]

[2]. Chaouki W, et al. Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. Fundam Clin Pharmacol. 2009 Oct;23(5):549-56. [Content Brief]

[3]. Souza ACS, et al. Citral presents cytotoxic and genotoxic effects in human cultured cells. Drug Chem Toxicol. 2020 Jul;43(4):435-440. [Content Brief]

[4]. Zhao W, et al. Citral protects against LPS-induced endometritis by inhibiting ferroptosis through activating Nrf2 signaling pathway. Inflammopharmacology. 2023 Jun;31(3):1551-1558. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.5690 mL	32.8450 mL	65.6901 mL	164.2252 mL
	5 mM	1.3138 mL	6.5690 mL	13.1380 mL	32.8450 mL
	10 mM	0.6569 mL	3.2845 mL	6.5690 mL	16.4225 mL
	15 mM	0.4379 mL	2.1897 mL	4.3793 mL	10.9483 mL
	20 mM	0.3285 mL	1.6423 mL	3.2845 mL	8.2113 mL
	25 mM	0.2628 mL	1.3138 mL	2.6276 mL	6.5690 mL
	30 mM	0.2190 mL	1.0948 mL	2.1897 mL	5.4742 mL
	40 mM	0.1642 mL	0.8211 mL	1.6423 mL	4.1056 mL
	50 mM	0.1314 mL	0.6569 mL	1.3138 mL	3.2845 mL
	60 mM	0.1095 mL	0.5474 mL	1.0948 mL	2.7371 mL
	80 mM	0.0821 mL	0.4106 mL	0.8211 mL	2.0528 mL
	100 mM	0.0657 mL	0.3285 mL	0.6569 mL	1.6423 mL

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Citral

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Publications Citing Use of MedChemExpress (MCE) Citral

All Aldehyde Dehydrogenase (ALDH) Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Citral Related Classifications

Cat. No.: HY-N7083