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Cat. No.: HY-172876

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FLY26

Name: FLY26
Brand: MedChemExpress
SKU: HY-172876
Price: 150.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Based on 1 Customer Validation

FLY26 is a selective partial GluN2B antagonist with an IC₅₀ value of 0.64 μM. FLY26 partially inhibits the GluN2B subunit of NMDA receptors, reduces calcium ion influx and reactive oxygen species (ROS) production and activates the BDNF/TrkB/CREB neuroprotective signaling pathway to alleviate neuronal excitotoxicity and mitochondrial dysfunction. FLY26 is promising for research of neurological deficits caused by cerebral ischemia-reperfusion injury.

For research use only. We do not sell to patients.

Purity : 99.66%
Formula: C₂₂H₂₃N₅O₃
Molecular Weight:405.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

FLY26 Chemical Structure

Size

Price

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Quantity

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

TrkB	NMDA Receptor

All iGluR Isoforms :

All Trk Receptor Isoforms :

Chemical Information

Appearance Solid
Molecular Weight 405.45
Formula C₂₂H₂₃N₅O₃
Color White to off-white
SMILES

O=C(OCC)C1=CN(C=C(C2=CC=C(N=CN(CCN(C)C)C3=O)C3=C2)C=C4)C4=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (308.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4664 mL

12.3320 mL

24.6640 mL

5 mM

0.4933 mL

2.4664 mL

4.9328 mL

10 mM

0.2466 mL

1.2332 mL

2.4664 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fan Y, et al. A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats. Bioorg Chem. 2025 Apr 30;161:108547. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4664 mL	12.3320 mL	24.6640 mL	61.6599 mL
	5 mM	0.4933 mL	2.4664 mL	4.9328 mL	12.3320 mL
	10 mM	0.2466 mL	1.2332 mL	2.4664 mL	6.1660 mL
	15 mM	0.1644 mL	0.8221 mL	1.6443 mL	4.1107 mL
	20 mM	0.1233 mL	0.6166 mL	1.2332 mL	3.0830 mL
	25 mM	0.0987 mL	0.4933 mL	0.9866 mL	2.4664 mL
	30 mM	0.0822 mL	0.4111 mL	0.8221 mL	2.0553 mL
	40 mM	0.0617 mL	0.3083 mL	0.6166 mL	1.5415 mL
	50 mM	0.0493 mL	0.2466 mL	0.4933 mL	1.2332 mL
	60 mM	0.0411 mL	0.2055 mL	0.4111 mL	1.0277 mL
	80 mM	0.0308 mL	0.1541 mL	0.3083 mL	0.7707 mL
	100 mM	0.0247 mL	0.1233 mL	0.2466 mL	0.6166 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

FLY26

All iGluR Isoforms

All Trk Receptor Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Solvent & Solubility

In Vitro:

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

FLY26 Related Classifications

HY-172876 Related Classifications

Bioz

Keywords

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