Fustin
Based on 1 Customer Validation
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- Purity: 99.6%
- CAS No.: 20725-03-5
- Formula: C15H12O6
- Molecular Weight:288.25
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>100 μg/mL
Compound: 21
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Cytotoxicity in human K562 cells by SRB assay
Cytotoxicity in human K562 cells by SRB assay
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[PMID: 28793973] |
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Decreased freezing response in Aβ-treated C57BL/6 mice.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.
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Animal Model:Aβ-treated C57BL/6 mice[1]
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Dosage:50 and 100 mg/kg
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Administration:Oral administration;daily, for 11days
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Result:Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.
Chemical Information
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CAS No. 20725-03-5
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Appearance Solid
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Molecular Weight 288.25
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Formula C15H12O6
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Color White to off-white
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SMILES
OC1=CC([C@H]2OC3=CC(O)=CC=C3C([C@@H]2O)=O)=CC=C1O
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Synonyms
(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (346.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4692 mL | 17.3461 mL | 34.6921 mL | 86.7303 mL |
| 5 mM | 0.6938 mL | 3.4692 mL | 6.9384 mL | 17.3461 mL | |
| 10 mM | 0.3469 mL | 1.7346 mL | 3.4692 mL | 8.6730 mL | |
| 15 mM | 0.2313 mL | 1.1564 mL | 2.3128 mL | 5.7820 mL | |
| 20 mM | 0.1735 mL | 0.8673 mL | 1.7346 mL | 4.3365 mL | |
| 25 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4692 mL | |
| 30 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8910 mL | |
| 40 mM | 0.0867 mL | 0.4337 mL | 0.8673 mL | 2.1683 mL | |
| 50 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7346 mL | |
| 60 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4455 mL | |
| 80 mM | 0.0434 mL | 0.2168 mL | 0.4337 mL | 1.0841 mL | |
| 100 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL |
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