Khellin
Based on 2 publication(s) in Google Scholar
Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.
For research use only. We do not sell to patients.
- Purity: 99.66%
- CAS No.: 82-02-0
- Formula: C14H12O5
- Molecular Weight:260.24
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Khellin
MoreAll EGFR Isoforms
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Biological Activity
IC50: 0.15 µM (EGFR)[1]
Chemical Information
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CAS No. 82-02-0
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Appearance Solid
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Molecular Weight 260.24
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Formula C14H12O5
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Color White to light yellow
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SMILES
O=C1C=C(C)OC2=C(OC)C(OC=C3)=C3C(OC)=C12
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Selective inhibition of monoamine oxidase B represents a therapeutic strategy for diabetic peripheral neuropathy. [Abstract]2026 Mar 19. PMID: 41857368 -
Int J Mol Sci
In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells. [Abstract]2024 Jul 16;25(14):7798. PMID: 39063039
Solvent & Solubility
DMSO : 16.67 mg/mL (64.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81. [Content Brief]
[2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8426 mL | 19.2130 mL | 38.4261 mL | 96.0652 mL |
| 5 mM | 0.7685 mL | 3.8426 mL | 7.6852 mL | 19.2130 mL | |
| 10 mM | 0.3843 mL | 1.9213 mL | 3.8426 mL | 9.6065 mL | |
| 15 mM | 0.2562 mL | 1.2809 mL | 2.5617 mL | 6.4043 mL | |
| 20 mM | 0.1921 mL | 0.9607 mL | 1.9213 mL | 4.8033 mL | |
| 25 mM | 0.1537 mL | 0.7685 mL | 1.5370 mL | 3.8426 mL | |
| 30 mM | 0.1281 mL | 0.6404 mL | 1.2809 mL | 3.2022 mL | |
| 40 mM | 0.0961 mL | 0.4803 mL | 0.9607 mL | 2.4016 mL | |
| 50 mM | 0.0769 mL | 0.3843 mL | 0.7685 mL | 1.9213 mL | |
| 60 mM | 0.0640 mL | 0.3202 mL | 0.6404 mL | 1.6011 mL |
Khellin Related Classifications
HY-B1394 Related Classifications
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