PluriSIn #2
Based on 3 publication(s) in Google Scholar
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 56563-17-8
- Formula: C11H8FN3O3
- Molecular Weight:249.20
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
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Publications Citing Use of MedChemExpress (MCE) PluriSIn #2
MoreAll Topoisomerase Isoforms
More
Biological Activity
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topoisomerase II alpha |
PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B153 and HUES9 human pluripotent stem cells (hPSCs)
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Concentration:20 µM
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Incubation Time:12 hours
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Result:Reduced TOP2A expression at the protein level.
Chemical Information
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CAS No. 56563-17-8
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Appearance Solid
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Molecular Weight 249.20
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Formula C11H8FN3O3
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Color White to off-white
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SMILES
O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Scopoletin alleviates cognitive deficits in 5xFAD mice via suppressing microglial inflammatory response. [Abstract]2026 Apr:153:157981. PMID: 41722121 -
Mol Med
TOP2A deficiency leads to human recurrent spontaneous abortion and growth retardation of mouse pre-implantation embryos. [Abstract]2022 Dec 30;28(1):165. PMID: 36585615 -
J Inflamm Res
Exploring The Role of TOP2A in the Intersection of Pathogenic Mechanisms Between Rheumatoid Arthritis and Idiopathic Pulmonary Fibrosis Based on Bioinformatics. [Abstract]2025 Mar 11:18:3449-3468. PMID: 40093950
Solvent & Solubility
DMSO : 5 mg/mL (20.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0128 mL | 20.0642 mL | 40.1284 mL | 100.3210 mL |
| 5 mM | 0.8026 mL | 4.0128 mL | 8.0257 mL | 20.0642 mL | |
| 10 mM | 0.4013 mL | 2.0064 mL | 4.0128 mL | 10.0321 mL | |
| 15 mM | 0.2675 mL | 1.3376 mL | 2.6752 mL | 6.6881 mL | |
| 20 mM | 0.2006 mL | 1.0032 mL | 2.0064 mL | 5.0161 mL |
PluriSIn #2 Related Classifications
HY-111630 Related Classifications
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