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VHB937

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Based on 1 Customer Validation

VHB937 is a potent and selective TREM2 agonist, a human monoclonal antibody, with sub-nanomolar affinity. VHB937 enhances TREM2 surface expression and downstream signaling, such as Syk phosphorylation and calcium mobilization. VHB937 exhibits robust neuroprotective effects in vivo, significantly reducing pathology and pro-inflammatory markers across a broad range of animal models of neuroinflammation and neurodegeneration. VHB937 can be used for neurodegenerative diseases research.

For research use only. We do not sell to patients.

  • Purity: 99.9%
  • Molecular Weight:145.72 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for VHB937
  • VHB937 Chemical Structure
    VHB937 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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VHB937 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All TREM receptor Isoforms

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All Calcium Channel Isoforms

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100 mg

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Assay Types
  • 1/16

    Immobilized huTREM2-ECD-hFc-Biotin can bind VHB937. The EC50 for this effect is 47.52 ng/mL.

  • VHB937 Chemical Structure
    1/16
  • VHB937
  • Immobilized huTREM2-ECD-hFc-Biotin can bind VHB937. The EC50 for this effect is 47.52 ng/mL.