308-R
308-R is a SGK3/SGK1/S6K1 inhibitor. 308-R exhibits an IC50 of 5 nM against human SGK3, an IC50 of 10 nM against human SGK1, and an IC50 of 1 nM against human S6K1. 308-R can be used in breast cancer research. It is also applicable to studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC SGK3 degrader-2 (HY-176823).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2376724-98-8
- 分子式: C23H23FN6O4S
- 分子量:498.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
SGK3 5 nM (IC50) |
SGK1 10 nM (IC50) |
S6K1 1 nM (IC50) |
体外実験
308-R potently inhibits SGK3, SGK1, and S6K1 kinases in vitro with IC50 values of 5 nM, 10 nM, and 1 nM, respectively[1].
308-R (1 μM; 8 h) potently suppresses NDRG1 Thr346 phosphorylation in HEK293 cells when combined with Akt inhibition, while 308-R (1 μM; 8 h) has minimal effect under basal conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HEK293 cells
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Concentration:1 μM (basal conditions); 1 μM (combination with Akt inhibition)
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Incubation Time:8 h (basal conditions); 8 h (combination with Akt inhibition)
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Result:Exerted minimal effect on phosphorylation of NDRG1 at Thr346 under basal conditions without Akt inhibition.
Markedly suppressed phosphorylation of NDRG1 at Thr346 in the presence of Akt inhibition.
化学情報
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CAS 番号 2376724-98-8
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分子量 498.53
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分子式 C23H23FN6O4S
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SMILES
CC1=CC=C(C(S(=O)(NC2=CC=C(C=C2)C3=NC(OC[C@H]4CNCCO4)=C5C=NNC5=N3)=O)=C1)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
プロトコル
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
308-R 関連分類
HY-151009 関連分類
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