447C88
447C88 is an acyl-coenzyme A cholesterol acyltransferase (ACAT) inhibitor with an IC50 of 23 nM. 447C88 can reduce plasma cholesterol levels and can be used in the research of endocrine and metabolic diseases such as hyperlipidemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 130400-16-7
- 分子式: C27H38F2N2O
- 分子量:444.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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ACAT 23 nM (IC50) |
化学情報
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CAS 番号 130400-16-7
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分子量 444.60
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分子式 C27H38F2N2O
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SMILES
O=C(NCCCCCCC)NC1=C(F)C=C(F)C=C1CCC2=CC=C(CC(C)(C)C)C=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Fraser IJ, et al. Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry. J Chromatogr B Biomed Appl. 1995 Jan 20;663(2):275-87. [Content Brief]
[2]. Peck RW, et al. The tolerability, pharmacokinetics and lack of effect on plasma cholesterol of 447C88, an AcylCoA: Cholesterol Acyl Transferase (ACAT) inhibitor with low bioavailability, in healthy volunteers. Eur J Clin Pharmacol. 1995;49(3):243-9. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
447C88 関連分類
HY-19112 関連分類
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