6'-Sialyllactose sodium
Based on 1 publication(s) in Google Scholar
6'-Sialyllactose sodium promotes the growth of beneficial bacteria (such as Bifidobacterium and lactobacillus) and inhibits the proliferation of harmful bacteria. 6'-Sialyllactose sodium exhibits anti-inflammatory and anti-angiogenic activities. 6'-Sialyllactose sodium promotes the muscle health.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.05%
- CAS 番号: 157574-76-0
- 分子式: C23H38NNaO19
- 分子量:655.53
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-108065A
3'-Sialyllactose sodiumPrebiotic -
HY-N9965
2'-FucosyllactoseImmunomodulator -
HY-N9448
Lacto-N-tetraoseOligosaccharides -
HY-N10521
6'-SialyllactoseMilk Oligosaccharide -
HY-N0379
D-MannoseEndogenous Metabolite -
HY-N0029
Forsythoside BTNF Inhibitor -
HY-N2579
1-KestoseEndogenous Metabolite -
HY-N9445
Lacto-N-neotetraoseEndogenous Metabolite -
HY-108065AR
3'-Sialyllactose sodium (Standard)Prebiotic -
HY-N10528
3-FucosyllactoseFucosylated Oligosaccharide -
HY-N2579R
1-Kestose (Standard)Endogenous Metabolite -
HY-17423
AbacavirReverse Transcriptase Inhibitor
MedChemExpress（MCE）の使用を引用している文献 6'-Sialyllactose sodium
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生物活性
製品説明
体外実験
6'-Sialyllactose sodium (0-50 μM, 24 h) inhibits Dihydrotestosterone-induced proliferation of HUVECs, suppresses tubular structure formation, inhibits the activation of VEGFR-2-related Akt-ERK signaling pathway[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HUVEC
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Concentration:0-50 μM
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Incubation Time:24 h
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Result:Downregulated levels of p-Akt and p-ERK.
体内実験
6'-Sialyllactose sodium (100 mg/kg, po, once daily, 5 times a week for 12 weeks) increases the muscle mass and strength, thereby improving the exercise endurance of mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SDR-stressed mouse model[2]
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Dosage:5% added to mouse diet
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Administration:po, 2 weeks
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Result:Reduced the anxiety-like behavior in open field tests.
Maintained the number of DCX-positive cells in the hippocampus.
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Animal Model:C57BL/6J mouse models[3]
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Dosage:100 mg/kg
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Administration:po, once daily, 5 times a week for 12 weeks
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Result:Increased the mouse running distance.
Increased the absolute weight of gastrocnemius and soleus muscles.
化学情報
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CAS 番号 157574-76-0
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性状 Solid
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分子量 655.53
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分子式 C23H38NNaO19
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Color White to off-white
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SMILES
O=C([C@](O[C@@]([C@@H]1NC(C)=O)([H])[C@H](O)[C@H](O)CO)(C[C@@H]1O)OC[C@H]([C@@H]([C@@H]2O)O)O[C@H]([C@@H]2O)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[Na]
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Future Sci OA
The potential of human milk oligosaccharides in ameliorating traumatic brain injury-induced cognitive impairment in mice. [Abstract]2026 Dec;12(1):2622241. PMID: 41622772
溶剤 & 溶解度
体外:
H2O : 100 mg/mL (152.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 12.5 mg/mL (19.07 mM); Clear solution; Need ultrasonic
プロトコル
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
純度とドキュメンテーション
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データシート (282 KB)
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SDS (394 KB)
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取扱説明書 (2659 KB)
参考文献
[2]. Tarr AJ, et al., The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis. Brain Behav Immun. 2015 Nov;50:166-177. [Content Brief]
[3]. Park EJ, et al., 6'-Sialyllactose Enhances Exercise Performance via Increased Muscle Mass and Strength. Nutrients. 2024 Aug 7;16(16):2600. [Content Brief]
[4]. Kim EY, et al., 6-sialyllactose ameliorates dihydrotestosterone-induced benign prostatic hyperplasia through suppressing VEGF-mediated angiogenesis. BMB Rep. 2019 Sep;52(9):560-565. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5255 mL | 7.6274 mL | 15.2548 mL | 38.1371 mL |
| 5 mM | 0.3051 mL | 1.5255 mL | 3.0510 mL | 7.6274 mL | |
| 10 mM | 0.1525 mL | 0.7627 mL | 1.5255 mL | 3.8137 mL | |
| 15 mM | 0.1017 mL | 0.5085 mL | 1.0170 mL | 2.5425 mL | |
| 20 mM | 0.0763 mL | 0.3814 mL | 0.7627 mL | 1.9069 mL | |
| 25 mM | 0.0610 mL | 0.3051 mL | 0.6102 mL | 1.5255 mL | |
| 30 mM | 0.0508 mL | 0.2542 mL | 0.5085 mL | 1.2712 mL | |
| 40 mM | 0.0381 mL | 0.1907 mL | 0.3814 mL | 0.9534 mL | |
| 50 mM | 0.0305 mL | 0.1525 mL | 0.3051 mL | 0.7627 mL | |
| 60 mM | 0.0254 mL | 0.1271 mL | 0.2542 mL | 0.6356 mL | |
| 80 mM | 0.0191 mL | 0.0953 mL | 0.1907 mL | 0.4767 mL | |
| 100 mM | 0.0153 mL | 0.0763 mL | 0.1525 mL | 0.3814 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
6'-Sialyllactose sodium 関連分類
HY-137335 関連分類
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