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A-1331852

55 Cited Publications
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Based on 55 publication(s) in Google Scholar

A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.

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  • 純度: 99.93%
  • CAS 番号: 1430844-80-6
  • 分子式: C38H38N6O3S
  • 分子量:658.81
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • A-1331852 Chemical Structure
    A-1331852 構造式
  • Experimental Validation Results for A-1331852
  • Experimental Validation Results for A-1331852
  • Experimental Validation Results for A-1331852
  • Experimental Validation Results for A-1331852
  • Experimental Validation Results for A-1331852
  • Experimental Validation Results for A-1331852
CAS 番号: 1430844-80-6
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  • A-1331852 Chemical Structure
    A-1331852 Chemical Structure
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  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2024 Jul;5(7):1082-1101. [Abstract]

    Customer Validation
     Growth inhibition curves (left panel), IC50 values, and AUCs (right panel) of OCI-AML2 cells treated with DMSO or 500nM ARM165 in combination with increasing doses (10-10000 nM）of either venetoclax, S63845, WEHI-539 and A-1331852. Error bars represent mean ± SD of three biological replicates composed of seven technical repeats after three days of seeding.

  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Cell. 2022 Apr 28;185(9):1521-1538.e18. [Abstract]

    Customer Validation
     Sensitivity of resting and pre-activated NK cells to BCL-XL inhibitor (A-1331852; 0-4096 nM; 24 h), as measured by annexin V staining.

  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Feb 1:554:216028. [Abstract]

    Customer Validation
     Xenotransplanted zebrafish larvae were treated with A-1331852 (10 μM; 48 h) (1 dpi - 3 dpi). Dot plots show relative changes of tumor area (3 dpi/1 dpi).

  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Nat Cancer. 2021 Jan;2(1):34-48. [Abstract]

    Customer Validation
     Representative cleaved caspase-3 staining and quantification of cleaved caspase-3-positive area in PDX 14–07 tumors treated with vehicle (n=21), abemaciclib (n=18), A-1331852 (25 mg/kg, p.o., every 12 hours, 3 doses in total) (n=15), or the combination (n=18). Mean ± s.d. of positively stained area are shown. P values were determined by Kruskal-Wallis, Dunn’s multiple comparisons test. Scale bars represent 100 μm.

  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jun 8;11(6):443. [Abstract]

    Customer Validation
     In A375 cells, knockdown (KD) of MCL1 (shMCL1), BCL2 (shBCL2), BCLW (shBCLW), and BCLXL (shBCLXL) lines are created by shRNA technology. shMCL1 (in presence of ABT-263 or A-1331852) shows significant reduction in cell viability during 48 h drug treatment.

  • 1/16

    A-1331852 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2020 Jun 8;11(6):443. [Abstract]

    Customer Validation
     Immunoblot with cell lysates collected after 48 h treatment with DMSO, single drugs: S63845 (156 nM) and A-1331852 (156 nM), or combinations, and probed for PARP. Both combinations increased the cleaved product of PARP. Molecular weight markers are in kDa.

  • A-1331852