アモキサピン
Based on 4 publication(s) in Google Scholar
Amoxapine (CL-67772) is a norepinephrine reuptake blocker and a 5-HT2/5-HT3 antagonist. Amoxapine can be used for the research of depression. Amoxapine has antibacterial activity. Amoxapine can enhance the killing effect of macrophages on mycobacterium by inducing autophagy, while protecting the cells from death.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 14028-44-5
- 分子式: C17H16ClN3O
- 分子量:313.79
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Amoxapine
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生物活性
5-HT Receptor and Serotonin Transporter[3]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | CC50 |
107.1 μM
Compound: Loxapine
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Cytotoxicity against mouse RAW264.7 cells assessed as reduction in number of cells by DAPI staining based high-content image analysis
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in number of cells by DAPI staining based high-content image analysis
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[PMID: 36439974] |
Amoxapine (10 μM; 3-48 h) reduces the cytotoxicity induced by mycobacterium bovis (BCG) and inhibits the survival of BCG in macrophages. The minimum inhibitory concentration (MIC90) for BCG is 53 μM[1].
Amoxapine (10 μM; 24 h) induces autophagy in mycobacteria-infected macrophages in a mTOR-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BCG treated RAW 264.7 cells
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Concentration:10 μM
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Incubation Time:3 h
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Result:Reduced the percentage of dead cells.
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Cell Line:BCG treated RAW 264.7 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly enhanced levels of LC3B-II protein and reduced levels of p62.
Significantly reduced the ratio of phosphorylation at Ser 2448 of mTOR to total mTOR.
Amoxapine (10 mg/kg; Intraperitoneal injection; 28 days) can affect the electrophysiology of rat atrial[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mtb strain H37Rv treated BALB/c and C57BL/6 mice[1]
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Dosage:3 and 5 mg/kg
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Administration:Oral administration (p.o.); 2 weeks
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Result:Significantly reduced bacterial burdens in the lungs.
Enhanced host defense against Mtb in vivo.
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Animal Model:Sprague-Dawley rats (200-300g)[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.); 28 days
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Result:Reduced atrial rate, contractile force and df/dtmax prolonged the sinus node recovery time and decreased atrial excitability.
Decreased amplitude and Vmax of the upstroke, prolonged the duration of the action potential (APD) and effective refractory period (ERP) and reduced the resting membrane potential.
Inhibited the slow action potentials and contractions induced by isoprenaline in Kdepolarized atria.
化学情報
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CAS 番号 14028-44-5
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性状 Solid
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分子量 313.79
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分子式 C17H16ClN3O
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Color White to light yellow
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SMILES
ClC1=CC=C(OC2=CC=CC=C2N=C3N4CCNCC4)C3=C1
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別名
Amoxapine; CL-67772
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (4)
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Journal Impact Factor
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Most Recent
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Nat Commun
Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells. [Abstract]2022 Nov 10;13(1):6796. PMID: 36357388
Amoxapine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6796. [Abstract]
10 µM Amoxapine (Amo), Desloratadine (Desl) and Maprotiline (Map) are incubated with HEK293T cells for 24 h and significantly inhibits PERK phosphorylation and expression of ATF4 and CHOP .
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J Med Chem
Exploring Simple Drug Scaffolds from the Generated Database Chemical Space Reveals a Chiral Bicyclic Azepane with Potent Neuropharmacology. [Abstract]2025 Apr 24. PMID: 40274264 -
PLoS Negl Trop Dis
Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]2019 Aug 20;13(8):e0007681. PMID: 31430351 -
溶剤 & 溶解度
DMSO : 8.33 mg/mL (26.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.56 mg/mL (4.97 mM); Clear solution
This protocol yields a clear solution of ≥ 1.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.56 mg/mL (4.97 mM); Clear solution
This protocol yields a clear solution of ≥ 1.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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参考文献
[1]. Wang J, et al. FDA-Approved Amoxapine Effectively Promotes Macrophage Control of Mycobacteria by Inducing Autophagy. Microbiol Spectr. 2022 Oct 26;10(5):e0250922. [Content Brief]
[2]. Delgado C, Manzanares J, Tamargo J, Valenzuela C. Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria. Br J Pharmacol. 1986 Feb;87(2):317-25. [Content Brief]
[3]. Maudhuit C, et al. Effects of acute and chronic treatment with amoxapine and cericlamine on the sleep-wakefulness cycle in the rat. Neuropharmacology. 1994 Aug;33(8):1017-25. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1869 mL | 15.9343 mL | 31.8687 mL | 79.6716 mL |
| 5 mM | 0.6374 mL | 3.1869 mL | 6.3737 mL | 15.9343 mL | |
| 10 mM | 0.3187 mL | 1.5934 mL | 3.1869 mL | 7.9672 mL | |
| 15 mM | 0.2125 mL | 1.0623 mL | 2.1246 mL | 5.3114 mL | |
| 20 mM | 0.1593 mL | 0.7967 mL | 1.5934 mL | 3.9836 mL | |
| 25 mM | 0.1275 mL | 0.6374 mL | 1.2747 mL | 3.1869 mL |
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