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Calcipotriol

(別名: Calcipotriene; カルシポトリオール; MC 903)
46 Cited Publications
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Based on 46 publication(s) in Google Scholar

Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

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  • 純度: 99.93%
  • CAS 番号: 112965-21-6
  • 分子式: C27H40O3
  • 分子量:412.60
  • 保管条件:

    -20°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

  • Calcipotriol Chemical Structure
    Calcipotriol 構造式
  • Experimental Validation Results for Calcipotriol
  • Experimental Validation Results for Calcipotriol
  • Experimental Validation Results for Calcipotriol
  • Experimental Validation Results for Calcipotriol
  • Experimental Validation Results for Calcipotriol
  • Experimental Validation Results for Calcipotriol
CAS 番号: 112965-21-6
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  • Calcipotriol Chemical Structure
    Calcipotriol Chemical Structure
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  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13733. [Abstract]

    Customer Validation
     Calcipotriol (cal, 60 μg/kg; i.p., three times a week) decreases the proportion of fibres with a CSA of 200-400 μm2 and increases the proportion of fibres with a CSA of 1000-1400 μm2 in male SKO mice, whereas it does not affect female mice.

  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 Oct 4;10(40):eadp5332. [Abstract]

    Customer Validation
     Immunofluorescence staining of ELOVL6 in the MC903-treated skin from WT or cKO mice (I) or from C57BL6/J mice with MP3C or EtOH application (J). For the MC903-induced AD mouse model, 1 nmol of Calcipotriol (MC903), dissolved in 10 μl of ethanol, was applied daily to the ears of 7-week-old mice. For dorsal application, 4 nmol of MC903, dissolved in 40 μl of ethanol, was applied daily to the backs of the mice for the specified duration.

  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

    Customer Validation
     A significant number of infiltrating cells express both IL-31 (green) and MOMA-2 (red) in Calcipotriol (MC903)-treated mice.

  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

    Customer Validation
     Immunofluorescence staining. MC903 (Calcipotriol; 2 nmol/25 μL ethanol, applied to the earlobes once daily for 9 consecutive days)-treated mice show significant positive staining reactions for TSLP (green) at the epidermis (Fig, B) and periostin (green) in the dermis (Fig, C).

  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: J Allergy Clin Immunol. 2023 Mar;151(3):737-746.e6. [Abstract]

    Customer Validation
     Macroscopic and histopathological findings. Treatment of the earlobes with MC903 (Calcipotriol; 2 nmol/25 μL ethanol, applied to the earlobes once daily for 9 consecutive days) induces AD-like skin inflammation (left panel) with histopathological hyperkeratosis and acanthosis, accompanied by massive infiltrates in the dermis (middle panel) and TUG8+ basophils (red) (right panel).

  • 1/16

    Calcipotriol purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 Jan;44(1):178-188. [Abstract]

    Customer Validation
     Calcipotriol (Cal, 500 µM; 24 h) significantly stimulates VDR activation in HGC27 and AGS cells, but not in CAFs.

  • Calcipotriol