製品番号: HY-N1913

Danshensu

(別名: Dan shen suan A; Salvianic acid A)

9 Cited Publications

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.90%
CAS 番号: 76822-21-4
分子式: C₉H₁₀O₅
分子量:198.17

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Danshensu 構造式

CAS 番号: 76822-21-4

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NF-κB アイソフォーム固有の製品をすべて表示 :

体外実験

Danshensu (Dan shen suan A) potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC₅₀=0.31 μM) and Vero-E6 cell (IC₅₀=4.97 μM)^[1].
Danshensu (0-100 μM; for 24 h) at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells^[2].
Danshensu (0-100 μM; for 24 h)dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell^[2].
Danshensu (0-100 μM; for 24, 48, 72 h) does not have any cytotoxic effect on human oral cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[2]

Cell Line:

FaDu and Ca9-22 cells
Concentration:

25, 50, and 100 μM
Incubation Time:

24 h
Result:

At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

Western Blot Analysis^[2]

Cell Line:

FaDu and Ca9-22 cells
Concentration:

25, 50, and 100 μM
Incubation Time:

24 h
Result:

Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.

体内実験

Danshensu (Dan shen suan A; 25, 50, 100 mg/kg; oral administration daily for 7 continuous days or i.v. once) before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Adult BALB/c mice (male, 6-8 weeks, 20±2 g)^[1]
Dosage:

25, 50, 100 mg/kg
Administration:

Oral administration (daily for 7 continuous days) or i.v. (once)
Result:

Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.

化学情報

CAS 番号 76822-21-4
性状 Solid
分子量 198.17
分子式 C₉H₁₀O₅
Color White to gray
SMILES

OC1=C(C=CC(C[C@H](C(O)=O)O)=C1)O
別名

Dan shen suan A; Salvianic acid A
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Polyphenols
Initial Source
- Plants
- Labiatae
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (9)

All In Vivo Efficacy StudyWBIFHistological Imaging/Staining

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Journal Impact Factor

Phytomedicine

Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps. [Abstract]

2025 Feb:137:156378. PMID: 39818119

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) significantly increased the flap survival rate in the C57BL/6J mouse.

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) increased the protein expression of Cadherin5, MMP9, and VEGFA in the C57BL/6J mouse. Representative western blot images of Cadherin5, MMP9, and VEGFA in mouse skin tissue lysates, with density quantification and statistical analysis of protein levels in each group.

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed the number of blood vessels significantly decreased after ischemic injury of the skin flap. This result was reversed with the use of DSS.

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) increased average vessel density in mouse.

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed that the proportion of GSDMD-N and Caspase-1 positive cells was considerably higher following ischemic injury of the skin flap and notably reduced after DSS treatment. Immunofluorescence staining of Caspase-1 (red) on skin tissue sections from each group, with DAPI staining for cell nuclei (blue).

Danshensu purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]

Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) decreased the protein expression of GSDMD-N and Caspase-1 in C57BL/6 J mice.
Phytomedicine

Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis. [Abstract]

2023 May:113:154743. PMID: 36893672
Food Sci Hum Wellness

2025.
Cancer Immunol Immunother

Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC. [Abstract]

2025 Jun 30;74(8):256. PMID: 40586931
Eur J Pharmacol

Sodium Danshensu alleviates bone cancer pain by inhibiting the osteoclast differentiation and CGRP expression. [Abstract]

2025 Apr 5:992:177296. PMID: 39900329
J Inflamm Res

Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [Abstract]

2026 Jun 19:19:596461. PMID: 42345001
J Tradit Complement Med

Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rubicon axis. [Abstract]

2025 Feb 7;15(4):434-445. PMID: 40677544
Breast Cancer Res Treat

Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer. [Abstract]

2024 Dec;208(3):657-671. PMID: 39177932
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607

溶剤 & 溶解度

体外:

H₂O : 5 mg/mL (25.23 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

5.0462 mL

25.2309 mL

50.4617 mL

5 mM

1.0092 mL

5.0462 mL

10.0923 mL

10 mM

0.5046 mL

2.5231 mL

5.0462 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 10 mg/mL (50.46 mM); Clear solution; Need ultrasonic and heat to 60°C

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. [Content Brief]

[2]. V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. [Content Brief]

[3]. Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	5.0462 mL	25.2309 mL	50.4617 mL	126.1543 mL
	5 mM	1.0092 mL	5.0462 mL	10.0923 mL	25.2309 mL
	10 mM	0.5046 mL	2.5231 mL	5.0462 mL	12.6154 mL
	15 mM	0.3364 mL	1.6821 mL	3.3641 mL	8.4103 mL
	20 mM	0.2523 mL	1.2615 mL	2.5231 mL	6.3077 mL
	25 mM	0.2018 mL	1.0092 mL	2.0185 mL	5.0462 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Danshensu

9 Cited Publications

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Danshensu

Antioxidant Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Anti-Cardiovascular Disease Compound Library

Ferroptosis Compound Library

Medicine Food Homology Compound Library

Phenols Library

Pyroptosis Compound Library

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Anti-Fibrosis Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

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RO5 Drug-like Natural Product Library

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High-Throughput Natural Product Library

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Mass Spectrometry Natural Product Library

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Natural Product and Natural Product-Like Compound Library

Anti-Infection Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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NF-κB Signaling Compound Library

Stem Cell Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Antiviral Compound Library

Anti-Aging Compound Library

MedChemExpress（MCE）の使用を引用している文献 Danshensu

NF-κB アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (9)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Danshensu 関連分類

HY-N1913 関連分類