GNE 220
GNE-220 is a potent and selective inhibitor of MAP4K4 with an IC50 of 7 nM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1199590-75-4
- 分子式: C25H26N8
- 分子量:438.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-100343
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HY-19562
PF-06260933MAP4K4 Inhibitor -
HY-100343R
GNE-495 (Standard)MAP4K4 Inhibitor -
HY-111754
DMX-5804MAP4K4 Inhibitor -
HY-125012
MAP4K4-IN-3MAP4K4 Inhibitor -
HY-138742
HPK1-IN-7HPK1 Inhibitor -
HY-138569
HPK1-IN-4HPK1 Inhibitor -
HY-U00428A
GNE 220 hydrochloride -
HY-132926
HPK1-IN-8 -
HY-145107
HPK1-IN-19HPK1 Inhibitor
MAP4K アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
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MAP4K4 7 nM (IC50) |
MAP4K5 9 nM (IC50) |
MAP4K6 1.1 μM (IC50) |
体外実験
GNE-220 also inhibits a few other kinases with IC50s of 9 nM, 476 nM and 1.1 μM for MINK (MAP4K6), DMPK and KHS1 (MAP4K5), respectively. GNE-220 alters human umbilical vein endothelial cells (HUVEC) sprout morphology. GNE-220 also reduces pERM+ retraction fibres in a dose-dependent manner. GNE-220 also dose-dependently increased the number of active-INTβ1+ long focal adhesions (FAs)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1199590-75-4
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分子量 438.53
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分子式 C25H26N8
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SMILES
CN1N=CC(C2=NC(C)=C(NC3=NC=C(C4=CC=C(N5CCN(C)CC5)C=C4)C=C36)C6=N2)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GNE 220 関連分類
HY-U00428 関連分類
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