Iberin
Based on 2 publication(s) in Google Scholar
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC50 of 2.3 μM in HL60 cell. Iberin induces apoptosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 505-44-2
- 分子式: C5H9NOS2
- 分子量:163.26
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保管条件:
Solution, -20°C, 2 years
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-13755
SulforaphaneKeap1/Nrf2/ARE Inducer -
HY-77813
Benzyl isothiocyanateCancer Preventive Agent -
HY-121323
ErucinAnticancer Activity -
HY-N1916
Coniferyl ferulateGST Inhibitor -
HY-15449
KaempferideAnti-cancer/Anti-inflammatory/Antioxidant -
HY-10006
Flavopiridol HydrochlorideCDK Inhibitor -
HY-A0166S
Cilastatin-15N,d3Stable Isotope -
HY-N1417
SesamolApoptosis Inducer -
HY-N4098
Incensole AcetateApoptosis Modulator -
HY-N2492
(E)-Methyl 4-coumarateDerivative Of Cinnamic Acid -
HY-15449R
Kaempferide (Standard) -
HY-N2492R
(E)-Methyl 4-coumarate (Standard)Standard Of (E)-Methyl 4-coumarate
MedChemExpress（MCE）の使用を引用している文献 Iberin
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
IC50: 2.3 μM (HL60 cell)[1]
体外実験
Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP[2]. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 505-44-2
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性状 Liquid
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分子量 163.26
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分子式 C5H9NOS2
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Color Colorless to light yellow
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SMILES
O=S(CCCN=C=S)C
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別名
NSC 321801
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Prod Res
Bioactivity-guided characterisation of iberin from Cakile edentula (Bigelow) Hook. inducing apoptosis in human melanoma cells. [Abstract]2025 Jun 5:1-7. PMID: 40470544 -
Biomed Pharmacother
Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression. [Abstract]2021 Oct:142:111533. PMID: 34148735
純度とドキュメンテーション
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データシート (272 KB)
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SDS (565 KB)
- English - EN (565 KB)
- Français - FR (565 KB)
- Deutsch - DE (565 KB)
- Norwegian - NO (565 KB)
- Español - ES (565 KB)
- Swedish - SV (565 KB)
- Italian - IT (565 KB)
- Korean - KR (565 KB)
- Portuguese - PT (565 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jakubikova J, et al. Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3375-86. [Content Brief]
[2]. Jadhav U, et al. Iberin induces cell cycle arrest and apoptosis in human neuroblastoma cells. [Content Brief]
[3]. Jadhav U, et al. Dietary isothiocyanate iberin inhibits growth and induces apoptosis in human glioblastoma cells. J Pharmacol Sci. 2007 Feb;103(2):247-51. [Content Brief]
[4]. Jakobsen TH, et al. Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorumsensing inhibitor of Pseudomonas aeruginosa. Appl Environ Microbiol. 2012 Apr;78(7):2410-21. [Content Brief]
[5]. Munday R, et al. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7):1867-71. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Iberin 関連分類
HY-101413 関連分類
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