L-701324
Based on 1 Customer Validation
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM). L-701324 has antidepressant activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.85%
- CAS 番号: 142326-59-8
- 分子式: C21H14ClNO3
- 分子量:363.79
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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NMDA Receptor |
L-701324 (5-10 mg/kg; i.p.; daily, for 2 weeks) produces strong antidepressant-like effects in the chronic unpredictable mild stress (CUMS) model of depression and prevents the CUMS-induced decreases in eurogenesis and the BDNF signaling cascade in the hippocampus[1].
L-701324 (2.5-5 mg/kg; p.o.; once) inhibits NMDA receptor activity via a blockade of the NMDA/glycine-sensitive site at the NMDA receptor is accompanied by a reduction of anxiety-like behavior in both non-conditioned and conditioned conflict behavior situations[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 J mice in the chronic unpredictable mild stress (CUMS) (7 weeks of age) [1]
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Dosage:5 and 10 mg/kg
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Administration:Intraperitoneal injection; daily, for 2 weeks
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Result:Reduced the immobility of C57BL/6 J mice.
Increased the expression of BDNF, pTrkB and pCREB in the hippocampus.
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Animal Model:Male C57BL/6 J mice in the forced swim test (FST) and tail suspension test (TST) (7 weeks of age)[1]
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Dosage:5 and 10 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Reduced the immobility of C57BL/6 J mice in the FST and TST.
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Animal Model:Male Sprague-Dawley rats (280-300 g)[2]
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Dosage:2.5 and 5 mg/kg
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Administration:Oral administration; once
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Result:Increased in the percentage of time spent in the open arm in a dose-dependent.
Increased punished responding in the Vogel's conflict test in a dose-dependent fashion.
化学情報
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CAS 番号 142326-59-8
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性状 Solid
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分子量 363.79
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分子式 C21H14ClNO3
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Color White to off-white
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SMILES
O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : ≥ 34 mg/mL (93.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Liu L, et, al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behav Brain Res. 2021 Feb 5;399:113038. [Content Brief]
[2]. Kotlinska J, et, al. A characterization of anxiolytic-like actions induced by the novel NMDA/glycine site antagonist, L-701,324. Psychopharmacology (Berl). 1998 Jan;135(2):175-81. [Content Brief]
[3]. Hutson PH, et, al. L-701,324, a glycine/NMDA receptor antagonist, blocks the increase of cortical dopamine metabolism by stress and DMCM. Eur J Pharmacol. 1997 May 20;326(2-3):127-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7488 mL | 13.7442 mL | 27.4884 mL | 68.7210 mL |
| 5 mM | 0.5498 mL | 2.7488 mL | 5.4977 mL | 13.7442 mL | |
| 10 mM | 0.2749 mL | 1.3744 mL | 2.7488 mL | 6.8721 mL | |
| 15 mM | 0.1833 mL | 0.9163 mL | 1.8326 mL | 4.5814 mL | |
| 20 mM | 0.1374 mL | 0.6872 mL | 1.3744 mL | 3.4360 mL | |
| 25 mM | 0.1100 mL | 0.5498 mL | 1.0995 mL | 2.7488 mL | |
| 30 mM | 0.0916 mL | 0.4581 mL | 0.9163 mL | 2.2907 mL | |
| 40 mM | 0.0687 mL | 0.3436 mL | 0.6872 mL | 1.7180 mL | |
| 50 mM | 0.0550 mL | 0.2749 mL | 0.5498 mL | 1.3744 mL | |
| 60 mM | 0.0458 mL | 0.2291 mL | 0.4581 mL | 1.1453 mL | |
| 80 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8590 mL |
L-701324 関連分類
HY-18698 関連分類
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