Copy Link Print Information

Protoporphyrin IX

(別名: プロトポルフィリンIX; Protoporphyrin IX)
22 Cited Publications
カスタマーレビュー

Based on 22 publication(s) in Google Scholar

Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 98.0%
  • CAS 番号: 553-12-8
  • 分子式: C34H34N4O4
  • 分子量:562.66
  • 保管条件:

    4°C, protect from light, stored under nitrogen

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light, stored under nitrogen)

  • Protoporphyrin IX Chemical Structure
    Protoporphyrin IX 構造式
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
  • Experimental Validation Results for Protoporphyrin IX
CAS 番号: 553-12-8
容量
価格（税別）
在庫状況
数量
Amount: USD 0.00
Please select quantity
or
or

* アイテムを追加する前、数量をご選択ください

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Protoporphyrin IX:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
  • 生物活性
  • 化学情報
  • 溶剤 & 溶解度
  • 純度とドキュメンテーション
  • 参考文献
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

MedChemExpress（MCE）の使用を引用している文献 Protoporphyrin IX

More
Customer Validation & Images
Bio/Physico-chemical AssayWBIFRT-PCROthersCell Imaging/Staining
  • Bio/Physico-chemical Assay
  • IF
  • IF
  • RT-PCR
  • Others
  • Cell Imaging/Staining
  • WB

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

More
Keywords
MOQ
Minimum order quantity
100 mg

お問い合わせ 在庫あり

Other size
お問い合わせ
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress ログイン
Register
Sign in to MedChemExpress
新規会員登録

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Protoporphyrin IX Chemical Structure
    Protoporphyrin IX Chemical Structure
    1/16
  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2024 Jun 21;22(1):358. [Abstract]

    Customer Validation
     UV-vis spectra of TPZ, Protoporphyrin IX, PP@PLGA, TP@PLGA and PTP@PLGA.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259. [Abstract]

    Customer Validation
     Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Protoporphyrin IX (for 49 h) and Verteporfin, displayed a complete suppression of viral CPE at 1.25 µmol/L and 0.31 µmol/L, respectively. Viral N protein expression in infected Vero E6 cells was assessed by immunofluorescence.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Antiviral effect and cell cytotoxicity of Protoporphyrin IX (0-320 μmol/L, 49 h) and verteporfin. The viral RNA production in the supernatant of infected Vero E6 cells was quantified with qRT-PCR.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Schematic presentation of treatment timing of Protoporphyrin IX and verteporfin. Briefly, Vero E6 cells were treated with Protoporphyrin IX, verteporfin or the solvent DMSO before viral infection, during viral entry and after viral entry. A total of 8 treatment groups (I–VIII) for each compound were set up.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Sci Bull. 2021 May 15;66(9):925-936. [Abstract]

    Customer Validation
     Blocking effect on ACE2 and SARS-CoV-2 S-mediated cell–cell fusion by Protoporphyrin IX (2.5 μmol/L, pre-treatment for one hour) and verteporfin. The inhibitory value of protoporphyrin IX or verteporfin-treated group was presented relative to that of the DMSO-treated group which was set as 100%, respectively.

  • 1/16

    Protoporphyrin IX purchased from MedChemExpress. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73. [Abstract]

    Customer Validation
     To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

  • Protoporphyrin IX