RG7800
Based on 5 publication(s) in Google Scholar
RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.88%
- CAS 番号: 1449598-06-4
- 分子式: C24H28N6O
- 分子量:416.52
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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MedChemExpress（MCE）の使用を引用している文献 RG7800
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
>10 μM
Compound: 2; RG7800
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Dark toxicity in mouse 3T3 cells assessed as decrease in cell viability by neutral red uptake assay
Dark toxicity in mouse 3T3 cells assessed as decrease in cell viability by neutral red uptake assay
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[PMID: 30044619] |
| NIH3T3 | IC50 |
330 nM
Compound: 2; RG7800
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Phototoxicity in mouse 3T3 cells assessed as decrease in cell viability in presence of UV light by neutral red uptake assay
Phototoxicity in mouse 3T3 cells assessed as decrease in cell viability in presence of UV light by neutral red uptake assay
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[PMID: 30044619] |
RG7800 increases the SMN protein level via induction of alternative splicing of the SMN2 mRNA. RG7800 is shown to promote the inclusion of exon 7 in SMN2 mRNA, generating full-length mRNA in vitro using fibroblasts from an SMA type I patient[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 1449598-06-4
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性状 Solid
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分子量 416.52
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分子式 C24H28N6O
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Color Off-white to yellow
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SMILES
O=C1C=C(C2=NN3C(C(CC)=NC(C)=C3)=C2)N=C4N1C=C(C5CCN(C)CC5)C=C4C
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別名
RO6885247
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2021 Aug;596(7871):291-295. PMID: 34321659 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Life Sci Alliance
Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology. [Abstract]2019 Mar 25;2(2):e201800268. PMID: 30910806 -
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溶剤 & 溶解度
1 M HCl : 100 mg/mL (240.08 mM; Need ultrasonic)
Ethanol : 2.5 mg/mL (6.00 mM; Need ultrasonic)
H2O : 1.25 mg/mL (3.00 mM; ultrasonic and adjust pH to 3 with HCl)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
Mice: Compounds (RG7800) are administered orally once daily (qd) for 10 days at three different doses (1, 3, and 10 mg/kg). One hour after the final dose, tissues are collected from the mice, and the level of the SMN protein is determined in the brain and quadriceps muscle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (273 KB)
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SDS (583 KB)
- English - EN (583 KB)
- Français - FR (583 KB)
- Deutsch - DE (583 KB)
- Norwegian - NO (583 KB)
- Español - ES (583 KB)
- Swedish - SV (583 KB)
- Italian - IT (583 KB)
- Korean - KR (583 KB)
- Portuguese - PT (583 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / Ethanol / 1 M HCl | 1 mM | 2.4008 mL | 12.0042 mL | 24.0085 mL | 60.0211 mL |
| Ethanol / 1 M HCl | 5 mM | 0.4802 mL | 2.4008 mL | 4.8017 mL | 12.0042 mL |
| 1 M HCl | 10 mM | 0.2401 mL | 1.2004 mL | 2.4008 mL | 6.0021 mL |
| 15 mM | 0.1601 mL | 0.8003 mL | 1.6006 mL | 4.0014 mL | |
| 20 mM | 0.1200 mL | 0.6002 mL | 1.2004 mL | 3.0011 mL | |
| 25 mM | 0.0960 mL | 0.4802 mL | 0.9603 mL | 2.4008 mL | |
| 30 mM | 0.0800 mL | 0.4001 mL | 0.8003 mL | 2.0007 mL | |
| 40 mM | 0.0600 mL | 0.3001 mL | 0.6002 mL | 1.5005 mL | |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL | 1.2004 mL | |
| 60 mM | 0.0400 mL | 0.2001 mL | 0.4001 mL | 1.0004 mL | |
| 80 mM | 0.0300 mL | 0.1501 mL | 0.3001 mL | 0.7503 mL | |
| 100 mM | 0.0240 mL | 0.1200 mL | 0.2401 mL | 0.6002 mL |
RG7800 関連分類
HY-101792 関連分類
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