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シンバスタチン

(別名: Simvastatin; MK 733)
88 Cited Publications
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Based on 88 publication(s) in Google Scholar

Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.

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  • 純度: 99.56%
  • CAS 番号: 79902-63-9
  • 分子式: C25H38O5
  • 分子量:418.57
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Simvastatin Chemical Structure
    Simvastatin 構造式
  • Experimental Validation Results for Simvastatin
  • Experimental Validation Results for Simvastatin
  • Experimental Validation Results for Simvastatin
  • Experimental Validation Results for Simvastatin
  • Experimental Validation Results for Simvastatin
CAS 番号: 79902-63-9
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  • Simvastatin Chemical Structure
    Simvastatin Chemical Structure
    1/16
  • 1/16

    Simvastatin purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 Aug;45(8):1010-1037. [Abstract]

    Customer Validation
     Denifanstat (10 mg/kg; i.g.; every day; from day7 to day20); Lovastatin(10 mg/kg; i.g.; every day; from day7 to day20); Simvastatin (50 mg/kg; i.g.; every day; from day7 to day20). Tumor growth curve of each group (4 mice/group). ns, not significant; * P < 0.05, **P < 0.01, ***P < 0.001.

  • 1/16

    Simvastatin purchased from MedChemExpress. Usage Cited in: Cancers (Basel). 2022 Nov 15;14(22):5601. [Abstract]

    Customer Validation
     Simvastatin (0-40 µM; 48 h) inhibits growth of REC-1 and Z-138 cells with IC50 values of 4.97 µM and 3.78 µM, respectively.

  • 1/16

    Simvastatin purchased from MedChemExpress. Usage Cited in: Clin Res Hepatol Gastroenterol. 2019 Apr;43(2):171-178. [Abstract]

    Customer Validation
     Simvastatin pretreatment maintains the expression of KLF2 and its protective target genes (eNOS and TM). Westernblot analysis of KLF2, phosphorylation eNOS and total eNOS in liver tissue. β-actin is normalized as the loading control.

  • 1/16

    Simvastatin purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2018 Sep 14;293(37):14328-14341. [Abstract]

    Customer Validation
     C4-2R cells are treated with Simvastatin, MDV3100 or combination of the two drugs at the indicated concentrations for 48 hours, followed by Immunoblotting (IB) against cleaved PARP.

  • 1/16

    Simvastatin purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2017:2017:3861914. [Abstract]

    Customer Validation
     Simvastatin pretreatment maintains the expression of KLF2 and its protective target genes

  • Simvastatin