スクラロース
Based on 3 publication(s) in Google Scholar
Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 56038-13-2
- 分子式: C12H19Cl3O8
- 分子量:397.63
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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MedChemExpress（MCE）の使用を引用している文献 Sucralose
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Human Endogenous Metabolite |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 56038-13-2
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性状 Solid
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分子量 397.63
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分子式 C12H19Cl3O8
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Color White to off-white
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SMILES
ClC[C@]1(O[C@H](CCl)[C@@H](O)[C@@H]1O)O[C@H]([C@@H]([C@@H](O)[C@H]2Cl)O)O[C@@H]2CO
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別名
Sucralose; E955; Trichlorosucrose
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Cancer Immunol Res
NET-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. [Abstract]2022 Dec 2;10(12):1542-1558. PMID: 36255412 -
NPJ Sci Food
2026 Mar 24. PMID: 41876529 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
溶剤 & 溶解度
H2O : 100 mg/mL (251.49 mM; Need ultrasonic)
DMSO : 100 mg/mL (251.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (125.75 mM); Clear solution; Need ultrasonic
プロトコル
Sucralose is pulverized in a standard pelleted diet at concentrations 0, 500, 2,000, 8,000, and 16,000 ppm and is administered to five groups of male (n=117, 114, 90, 66, and 70, respectively) and five groups female (n=102, 105, 60, 65, and 64, respectively) Swiss mice from the 12th day of fetal life until death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (278 KB)
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SDS (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17. [Content Brief]
[2]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.5149 mL | 12.5745 mL | 25.1490 mL | 62.8725 mL |
| 5 mM | 0.5030 mL | 2.5149 mL | 5.0298 mL | 12.5745 mL | |
| 10 mM | 0.2515 mL | 1.2575 mL | 2.5149 mL | 6.2873 mL | |
| 15 mM | 0.1677 mL | 0.8383 mL | 1.6766 mL | 4.1915 mL | |
| 20 mM | 0.1257 mL | 0.6287 mL | 1.2575 mL | 3.1436 mL | |
| 25 mM | 0.1006 mL | 0.5030 mL | 1.0060 mL | 2.5149 mL | |
| 30 mM | 0.0838 mL | 0.4192 mL | 0.8383 mL | 2.0958 mL | |
| 40 mM | 0.0629 mL | 0.3144 mL | 0.6287 mL | 1.5718 mL | |
| 50 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2575 mL | |
| 60 mM | 0.0419 mL | 0.2096 mL | 0.4192 mL | 1.0479 mL | |
| 80 mM | 0.0314 mL | 0.1572 mL | 0.3144 mL | 0.7859 mL | |
| 100 mM | 0.0251 mL | 0.1257 mL | 0.2515 mL | 0.6287 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sucralose 関連分類
HY-N0614 関連分類
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