A11 acetate
Based on 1 Customer Validation
A11 (ANXA1-derived 11 amino acid-long peptide) acetate is a ANXA1-EphA2 interaction-blocking peptide. A11 acetate reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 acetate inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 acetate inhibits angiogenesis. A11 acetate can be used in studies related to nasopharyngeal carcinoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.48%
- 分子式: C117H204N46O32.xC2H4O2
- 分子量:2767.16 (free base)
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
A11 (2.5-10 μM; 24 h) acetate blocks the binding of ANXA1 to EphA2, enhances the binding of Cbl to EphA2, reduces the protein level of EphA2 in human nasopharyngeal carcinoma 5-8F and HK1 cells in a dose-dependent manner, and promotes the ubiquitination and endocytosis of EphA2, with the strongest effect observed after 24 h of incubation at the treatment concentration of 10 μM[1].
A11 (10 μM; 10 days) acetate significantly inhibits the proliferation and anchorage-independent growth of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
A11 (10 μM; 24-48 h) acetate significantly inhibits the migration and invasion of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:refreshed every 24 h for 10 days
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Result:Reduced EdU-positive 5-8F cells from ~34% to ~14% and EdU-positive HK1 cells from ~26% to ~12%.
Reduced colony formation in 5-8F cells from ~350 colonies to ~100 colonies and in HK1 cells from ~300 colonies to ~50 colonies.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the invasion.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the migration.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 2767.16 (free base)
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分子式 C117H204N46O32.xC2H4O2
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Color White to off-white
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SMILES
OC1=CC=C(C=C1)C[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.CC(O)=O.[x]
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別名
ANXA1-derived 11 amino acid-long peptide acetate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
A11 acetate 関連分類
HY-P10412A 関連分類
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