A11
Based on 1 Customer Validation
A11 (ANXA1-derived 11 amino acid-long peptide) is a ANXA1-EphA2 interaction-blocking peptide. A11 reduces ANXA1 bound to EphA2 and increases Cbl (the E3 ubiquitin ligase of EphA2) bound to EphA2. A11 inhibits the proliferation, migration and invasion of nasopharyngeal carcinoma cells. A11 inhibits angiogenesis. A11 can be used in studies related to nasopharyngeal carcinoma.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.49%
- CAS 番号: 2412926-30-6
- 分子式: C117H204N46O32
- 分子量:2767.16
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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AnxA1 |
A11 (2.5-10 μM; 24 h) blocks the binding of ANXA1 to EphA2, enhances the binding of Cbl to EphA2, reduces the protein level of EphA2 in human nasopharyngeal carcinoma 5-8F and HK1 cells in a dose-dependent manner, and promotes the ubiquitination and endocytosis of EphA2, with the strongest effect observed after 24 h of incubation at the treatment concentration of 10 μM[1].
A11 (10 μM; 10 days) significantly inhibits the proliferation and anchorage-independent growth of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
A11 (10 μM; 24-48 h) significantly inhibits the migration and invasion of human nasopharyngeal carcinoma 5-8F and HK1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:refreshed every 24 h for 10 days
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Result:Reduced EdU-positive 5-8F cells from ~34% to ~14% and EdU-positive HK1 cells from ~26% to ~12%.
Reduced colony formation in 5-8F cells from ~350 colonies to ~100 colonies and in HK1 cells from ~300 colonies to ~50 colonies.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the invasion.
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Cell Line:human NPC 5-8F and HK1 cells
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Concentration:10 μM
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Incubation Time:24 and 48 h
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Result:Significantly inhibited the migration.
化学情報
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CAS 番号 2412926-30-6
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性状 Solid
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分子量 2767.16
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分子式 C117H204N46O32
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Color White to off-white
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別名
ANXA1-derived 11 amino acid-long peptide
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配列
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Glu-Tyr-Val-Gln-Thr-Val-Lys-Ser-Ser-Lys-Gly
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シーケンスの短縮
YGRKKRRQRRREYVQTVKSSKG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 33.33 mg/mL (12.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 22.2 mg/mL (8.02 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.3614 mL | 1.8069 mL | 3.6138 mL | 9.0345 mL |
| 5 mM | 0.0723 mL | 0.3614 mL | 0.7228 mL | 1.8069 mL | |
| DMSO | 10 mM | 0.0361 mL | 0.1807 mL | 0.3614 mL | 0.9035 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
A11 関連分類
HY-P10412 関連分類
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