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United States

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製品番号: HY-147522

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ADG-2e

ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2419951-75-8
分子式: C₄₂H₆₇N₁₁O₄
分子量:790.05

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

ADG-2e 構造式

CAS 番号: 2419951-75-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Antibiotic アイソフォーム固有の製品をすべて表示 :

体外実験

ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) ^[1].
ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration^[1].
ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility^[1].
ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Sheep red blood cells (sRBCs)
Concentration:

0-60 μg/mL
Incubation Time:

2 hours
Result:

Showed any hemolysis until 16 μg/mL and showed slight hemolysis at 32 μg/mL.

Cell Proliferation Assay^[1]

Cell Line:

Metastatic breastcancer cell line MDA-MB-231
Concentration:

0-100 μM
Incubation Time:

24 hours
Result:

No significant inhibitory effect on the proliferation of MDA-MB-231 cells.

Immunofluorescence^[1]

Cell Line:

Metastatic breastcancer cell line MDA-MB-231
Concentration:

0-40 μM
Incubation Time:

6 hours
Result:

Showed an increase in actin lamellipodium generation.

化学情報

CAS 番号 2419951-75-8
分子量 790.05
分子式 C₄₂H₆₇N₁₁O₄
SMILES

CC1=CN([C@H]2C[C@H](NC(CC34C[C@@H]5C[C@H](C3)C[C@H](C4)C5)=O)[C@@H](CNC(CC67C[C@@H]8C[C@H](C6)C[C@H](C7)C8)=O)O2)C(N=C1N(CCCNC(N)=N)CCCNC(N)=N)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sridhar Chirumarry, et al. Antibacterial AZT derivative regulates metastasis of breast cancer cells. Eur J Med Chem. 2020 May 1;193:112233. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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