製品番号: HY-148189

Aldometanib

(別名: LXY-05-029)

9 Cited Publications

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.65%
CAS 番号: 2904601-67-6
分子式: C₂₇H₄₃Cl₂IN₂
分子量:593.45

保管条件:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Aldometanib 構造式

CAS 番号: 2904601-67-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

AMPK アイソフォーム固有の製品をすべて表示 :

体外実験

Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Mouse primary hepatocytes, MEFs cells
Concentration:

0-1000 nM
Incubation Time:

2 h
Result:

Activated AMPK in mouse embryonic fibroblasts (MEFs) and mouse primary hepatocytes cells.

Immunofluorescence^[1]

Cell Line:

MEFs cells
Concentration:

5 nM
Incubation Time:

2 h
Result:

Inhibited TRPVs and induces AXIN lysosomal translocation.

体内実験

Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice^[1].
Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice^[1].
Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis^[1].
Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice^[1].
Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Lean mice^[1]
Dosage:

0-10 mpk
Administration:

Oral
Result:

Decreased fasting blood glucose and improved glucose tolerance, promoted muscular TBC1D1 phosphorylation and glucose uptake.

Animal Model:

Obese hyperglycaemic mice^[1]
Dosage:

2-10 mpk
Administration:

Oral, twice daily, for a week
Result:

Decreased blood glucose, lowered blood glucose in a muscular AMPK-dependent manner reduced hepatic TAG, improved insulin sensitivity, increased glucose disposal rates, inhibited TAG synthesis in liver and primary hepatocytes, decreased fat mass.

Animal Model:

NASH mice^[1]
Dosage:

2 mpk
Administration:

Oral, twice-daily, for a month
Result:

Decreased histological scores used to describe the features of NASH, reduced apoptosis rate of hepatic cells, inhibited inflammatory responses in the liver of NASH mice and improved glucose tolerance of NASH mice.

Animal Model:

C. elegans^[1]
Dosage:

0-50 μM
Administration:

Oral, 0-50 days
Result:

Promoted oxidative stress resistance and mitochondrial functions in C. elegans.

Animal Model:

C57BL/6 mice^[1]
Dosage:

100 μg/mL
Administration:

Oral
Result:

Extended lifespan, elevated NAD^＋ levels and mitochondrial oxidative respiration, rejuvenated muscle function in aged mice.

化学情報

CAS 番号 2904601-67-6
性状 Solid
分子量 593.45
分子式 C₂₇H₄₃Cl₂IN₂
Color White to light yellow
SMILES

CCCCCCCCCCCCCCCCN1C=C[N+](CC2=C(Cl)C=CC=C2Cl)=C1C.[I-]
別名

LXY-05-029
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (9)

All In Vivo Efficacy StudyBio/Physico-chemical AssayCell Imaging/StainingIHCWB

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Journal Impact Factor

Cell Res

Glucose starvation mimetic aldometanib removes immune barriers permitting mice with hepatocellular carcinoma to live to normal ages. [Abstract]

2025 Dec;35(12):934-953. PMID: 41286115

Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953. [Abstract]

Aldometanib treatment enables HCC-bearing mice to live to a similar age to normal mice. Wild-type C57BL/6 mice (4 weeks old) were intraperitoneally injected with DEN once a week for 2 weeks, followed by feeding with HFD 2 weeks later. The mice were then administered Aldometanib at 100 mg/L in drinking water starting at 12 weeks of age. The lifespans of HCC-bearing mice are shown as Kaplan–Meier curves.

Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953. [Abstract]

Aldometanib inhibits the growth of HCC in DEN-HFD mice. Mice were induced to develop HCC using DEN and HFD. Aldometanib at 50 mg/L, 100 mg/L, or 150 mg/L was administered in drinking water starting at week 12 of age, and tissue samples were collected at week 48. The numbers of tumors in each size/diameter category for each dosage of aldometanib are shown: 0–1 mm, 1–3 mm, 3–5 mm, 5–7 mm, 7–9 mm, and > 9 mm tumors.

Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2025 Dec;35(12):934-953. [Abstract]

Aldometanib (50-150 mg/L, drinking water) suppresses AFP levels in DEN-HFD mice. HCC tissues from aldometanib-treated and untreated DEN-HFD mice,were subjected to immunohistochemistry (IHC) staining for AFP.
Cell Res

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. [Abstract]

2024 Oct;34(10):683-706. PMID: 38898113

Aldometanib purchased from MedChemExpress. Usage Cited in: Cell Res. 2024 Oct;34(10):683-706. [Abstract]

Inhibition of glutaminolysis blocks the LPS-induced death in mice. WT mice were orally gavaged with 12.5 mg/kg BPTES, intraperitoneally injected with 10 mg/kg compound 968, or orally gavaged with 2 mg/kg Aldometanib. After 0.5 h of injection, mice were intraperitoneally injected with 10 mg/kg LPS, followed by determining their survival. Survival curves are displayed as Kaplan–Meier curves.
J Transl Med

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability. [Abstract]

2023 Nov 21;21(1):838. PMID: 37990271
Oncogene

Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer. [Abstract]

2024 Sep;43(39):2901-2913. PMID: 39164523
EMBO J

Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells. [Abstract]

2025 Jul;44(13):3669-3696. PMID: 40355555

Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696. [Abstract]

Luciferase-based assay for ATP measurement. Graph shows values of relative light units (RLU) normalized to total protein levels for each condition. Conditions are under resting or glucose stimulating conditions with the addition of DMSO (vehicle), Aldometanib (200 nM), pyruvate (20 mM) or rotenone (50 nM)

Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696. [Abstract]

Immunostaining for G3BP1 (green), eIF3b (red) and smRNA FISH for Ins1/2 (gray) under resting or stimulating glucose conditions the addition of DMSO (vehicle), Aldometanib (200 nM) or pyruvate (20 mM). Nuclei are stained with DAPI (blue).

Aldometanib purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 Jul;44(13):3669-3696. [Abstract]

Western blot p-AMPKα^Thr172, p-mTOR^Ser2448 and gamma-tubulin across varying conditions: resting and stimulating glucose concentrations, with and without aldometanib treatment as shown in the figure.
Cell Rep

CPSF1 inhibition promotes widespread use of intergenic polyadenylation sites and impairs glycolysis in prostate cancer cells. [Abstract]

2025 Jan 22;44(1):115211. PMID: 39847481
Life Metab

Hierarchical inhibition of mTORC1 by glucose starvation-triggered AXIN lysosomal translocation and by AMPK. [Abstract]

2023 Mar 1;2(3):load005. PMID: 39872013
Ann Clin Transl Neurol

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression. [Abstract]

2026 Mar 24. PMID: 41876403
Toxicon

Aldometanib mitigates LPS-induced lung fibroblasts injury through the activation of AMPK-mediated signaling pathways. [Abstract]

2025 Oct:265:108489. PMID: 40691951

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (168.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6851 mL

8.4253 mL

16.8506 mL

5 mM

0.3370 mL

1.6851 mL

3.3701 mL

10 mM

0.1685 mL

0.8425 mL

1.6851 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (4.21 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (277 KB)
SDS (252 KB)
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- Español - ES (252 KB)
- Swedish - SV (252 KB)
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- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chen-Song Zhang, et al. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct 10. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6851 mL	8.4253 mL	16.8506 mL	42.1265 mL
	5 mM	0.3370 mL	1.6851 mL	3.3701 mL	8.4253 mL
	10 mM	0.1685 mL	0.8425 mL	1.6851 mL	4.2127 mL
	15 mM	0.1123 mL	0.5617 mL	1.1234 mL	2.8084 mL
	20 mM	0.0843 mL	0.4213 mL	0.8425 mL	2.1063 mL
	25 mM	0.0674 mL	0.3370 mL	0.6740 mL	1.6851 mL
	30 mM	0.0562 mL	0.2808 mL	0.5617 mL	1.4042 mL
	40 mM	0.0421 mL	0.2106 mL	0.4213 mL	1.0532 mL
	50 mM	0.0337 mL	0.1685 mL	0.3370 mL	0.8425 mL
	60 mM	0.0281 mL	0.1404 mL	0.2808 mL	0.7021 mL
	80 mM	0.0211 mL	0.1053 mL	0.2106 mL	0.5266 mL
	100 mM	0.0169 mL	0.0843 mL	0.1685 mL	0.4213 mL

Keywords

Aldometanib

9 Cited Publications

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Aldometanib

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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

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High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 Aldometanib

AMPK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (9)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Aldometanib

Epigenetics Compound Library

Metabolism/Protease Compound Library

PI3K/Akt/mTOR Compound Library

Anti-Aging Compound Library

Antioxidant Compound Library

Anti-diabetic Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Lipid Metabolism Compound Library

Glucose Metabolism Compound Library

Pain-Related Compound Library

Radioprotector Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 Aldometanib

AMPK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (9)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Aldometanib 関連分類

HY-148189 関連分類