Allo-aca TFA
Based on 10 publication(s) in Google Scholar
Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C50H76F3N13O17
- 分子量:1188.21
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 Allo-aca TFA
More- Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]
- Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
- Stem Cell Res Ther. 2025 May 5;16(1):227. [Abstract]
- Int J Mol Sci. 2025 Oct 9;26(19):9819. [Abstract]
- Ann Med. 2024 Dec;56(1):2419990. [Abstract]
- J Endocr Soc. 2025 Dec 24.
- Cancer Res Treat. 2025 Apr;57(2):457-477. [Abstract]
- Andrology. 2025 Feb;13(2):371-381. [Abstract]
- bioRxiv. 2026 Jan 05.
- bioRxiv. 2023 Aug 14.
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Flow Cytometry
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WB
Neuropeptide Y Receptor アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1188.21
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分子式 C50H76F3N13O17
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シーケンスの短縮
{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (10)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases. [Abstract]2026 Mar 9;44(3):658-675.e12. PMID: 41687606
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]
KMplots and BLI analysis of the mice received chemotherapy along with Veh. or Allo-aca (1 mg/kg; i.p.; every two days) (n = 8 mice/group).
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Cell Death Dis
Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia. [Abstract]2026 Feb 23;17(1):249. PMID: 41730833
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Kaplan-Meier survival curve of MLL-AF9 AML mice (n = 5 mice per group).
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Representative H&E-stained sections of BM, spleen and liver (scale bars: 20 μm). The results showed that leptin (Allo-aca) (1 mg/kg; i.p.; once daily from days 11 to 20) dampened Ara-C cytotoxicity, extensive leukemic infiltration of liver and spleen.
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Representative FCM profiles (left) and quantification of YFP+ AML cells in BM, spleen, and liver of MLL-AF9 AML mice (n = 5 mice per group).
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Western blot analysis of LEPR expression in AML cells under indicated treatments (Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20), ect.). β-actin served as the loading control.
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Effect of Allo-aca on AML cell chemosensitivity by CCK-8 assay. The inhibition rates were calculated from eight treatment arms: (i) PBS; (ii) Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20) alone; (iii) Leptin alone; (iv) Allo-aca + Leptin; (v) Ara-C alone (or DNR); (vi) Allo-aca + Ara-C (or DNR); (vii) Leptin + Ara-C (or DNR) and (viii) Allo-aca + Leptin + Ara-C (or DNR).
Allo-aca TFA purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Mitochondrial respiration analysis of sorted MLL-AF9 AML cells using Seahorse XF technology (n = 5 mice per group).
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Stem Cell Res Ther
Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression. [Abstract]2025 May 5;16(1):227. PMID: 40325465 -
Int J Mol Sci
Cinnamaldehyde Inhibits Leptin-Induced MMP-1 by Modulating Leptin Receptor/STAT3 and Blocking RhoA/NF-κB Pathways in Human Intervertebral Disc Stem Cells. [Abstract]2025 Oct 9;26(19):9819. PMID: 41097084 -
Ann Med
Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway. [Abstract]2024 Dec;56(1):2419990. PMID: 39450935 -
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Cancer Res Treat
Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances ROS Generation in TNBC Cells. [Abstract]2025 Apr;57(2):457-477. PMID: 39164083 -
Andrology
Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]2025 Feb;13(2):371-381. PMID: 38778669 -
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純度とドキュメンテーション
参考文献
[1]. Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584. [Content Brief]
[2]. Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)