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製品番号: HY-184961

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Anticancer agent 353

Anticancer agent 353 is a heterobifunctional antitumor agent with weak ERα inhibitory activity and anticancer activity. Anticancer agent 353 exhibits growth inhibitory activity against MCF7 cells. Anticancer agent 353 can be used in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3099598-10-1
分子式: C₅₂H₅₈N₈OS
分子量:843.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 353 構造式

CAS 番号: 3099598-10-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]

ERα

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

体外実験

Anticancer agent 353 (III-146) exhibits growth inhibitory activity against MCF7 cells, with a GI₅₀ of < 0.05 μM^[1].
Anticancer agent 353 exhibits activity in both Doxorubicin (HY-15142A)-induced ERα-overexpressing and non-induced T-Rex 293 cells, with consistent antiproliferative activity between the two groups (GI₅₀ = 0.5-2.5 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3099598-10-1
分子量 843.13
分子式 C₅₂H₅₈N₈OS
SMILES

OC1=CC=C([C@@H](C2=CC=C(N3CC(C3)CN4CCN(CC4)CC5CN(C6=CC=C(C7=N[C@H](C)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C5)C=C2)[C@@H](C%10=CC=CC=C%10)CC%11)C%11=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Eastman KJ, et al. Heterobifunctional compounds and their use in treating disease. WO2025189056 A1. WIPO. 2025.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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