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製品番号: HY-187163

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Anticancer agent 355

Anticancer agent 355 is a highly selective and potent anticancer agent, with IC₅₀ values of 64.66 μM and 13.35 μM against HeLa and MDA-MB-231 cancer cells, respectively. Anticancer agent 355 induces plasmid DNA degradation via intercalation or minor groove binding, and disrupts the tertiary structure of BSA by interfering with the interactions of amino acid side chains. Anticancer agent 355 can be used in the research of cervical cancer and breast cancer.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 78831-35-3
分子式: C₁₆H₁₂N₂O₄
分子量:296.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticancer agent 355 構造式

CAS 番号: 78831-35-3

価格（税別）

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC50	64.66 μM	Cytotoxicity against human cervical cancer HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against human cervical cancer HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085
MDA-MB-231	IC50	13.35 μM	Cytotoxicity against human breast cancer MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against human breast cancer MDA-MB-231 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085
HEK293	IC50	82.75 μM	Cytotoxicity against normal human fibroblast HEK-293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against normal human fibroblast HEK-293 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	j.inoche.2020.108085

体外実験

Anticancer agent 355 (Compound S4) (1-3 mg/mL; 1 h) completely degrades plasmid DNA of approximately 1 kb, exhibiting strong chemical nuclease activity^[1].
Anticancer agent 355 (9-300 μM; 24 h) exhibits cytotoxicity against HeLa and MDA-MB-231 cancer cells, with IC₅₀ values of 64.66 μM and 13.35 μM, respectively. Meanwhile, compared to normal HEK-293 cells (IC₅₀ = 82.75 μM), this agent shows high selectivity for MDA-MB-231 cells, with a selectivity coefficient of 6.19^[1].
Anticancer agent 355 (30 µM) exhibits potent DNA-binding activity via an intercalation mode in in vitro biochemical reactions^[1].
Anticancer agent 355 binds to BSA in in vitro biochemical reactions, inducing fluorescence quenching and disruption of the protein's tertiary structure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 78831-35-3
分子量 296.28
分子式 C₁₆H₁₂N₂O₄
SMILES

O=C(C1=NC2=C3N=C(C(OC)=O)C=CC3=CC=C2C=C1)OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. De, Sourav, et al. "Highly selective and potent anti-cancer agents based on 2, 9-substituted-1, 10-phenanthroline derivatives." Inorganic Chemistry Communications 119 (2020): 108085.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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化学情報
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参考文献

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Anticancer agent 355

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示