Antimalarial agent 18
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3037689-82-7
- 分子式: C23H44NO9P
- 分子量:509.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Plasmodium |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | CC50 |
40.3 μM
Compound: 13j
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
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[PMID: 36399924] |
Antimalarial agent 18 (compound 13j) is the long chain octanoyl analog, shows cytotoxicity against MRC-5 fibroblasts with an IC50 value of 40.3 μM[1].
Antimalarial agent 18 poorly inhibits avirulent M. tuberculosis strain (H37Ra) with an IC50 value >64 μM[1].
Antimalarial agent 18 may serve as a lead for future analog development of MEP pathway inhibitors against Gram-negative pathogens in general, and A. baumannii in particular[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3037689-82-7
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分子量 509.57
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分子式 C23H44NO9P
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SMILES
CCCCCCCC(OCOP(CCCC(N(O)C)=O)(OCOC(CCCCCCC)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antimalarial agent 18 関連分類
HY-151965 関連分類
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