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製品番号: HY-187926

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Antimalarial agent 67

Antimalarial agent 67 is an orally active inositol acyltransferase Gwt1p inhibitor and antimalarial agent, with IC₅₀ values of 0.030 μM and 0.041 μM against P. falciparum 3D7 and K1 strains, respectively. Antimalarial agent 67 blocks inositol ring acylation by inhibiting the key enzyme Gwt1p in the GPI biosynthesis pathway of Plasmodium, thereby inhibiting parasite growth and maturation. Antimalarial agent 67 can be used for research on malaria.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2675491-09-3
分子式: C₂₁H₁₉F₆N₇O₂
分子量:515.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antimalarial agent 67 構造式

CAS 番号: 2675491-09-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Acyltransferase アイソフォーム固有の製品をすべて表示 :

体外実験

Parasitic Infection

Antimalarial agent 67 (compound VII) (0.001-1 μg/mL; 72 h) exhibits antimalarial activity against the erythrocytic stages of P. falciparum 3D7 and K1 strains in vitro, with IC₅₀ values of 0.030 μM and 0.041 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Parasitic Infection

Antimalarial agent 67 (Compound VII) (10 mL/kg; p.o.; once daily; for 3 consecutive days) exhibits antimalarial activity in a humanized immunodeficient NSG mouse model engrafted with human erythrocytes and infected with P. falciparum (Pf3D70087/N9)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NSG (NOD-scid IL-2RYnull) mice (female) were infected with P. falciparum (Pf3D70087/N9)^[1]
Dosage:

10 mL/kg
Administration:

p.o.; once daily; for 3 consecutive days
Result:

Demonstrated in vivo antimalarial efficacy, being able to significantly reduce parasitemia in peripheral blood. The daily dose that reduced parasitemia by 90% compared to untreated control animals at day seven post-infection (ED90) was 6.2 mg/kg/day.

化学情報

CAS 番号 2675491-09-3
分子量 515.42
分子式 C₂₁H₁₉F₆N₇O₂
SMILES

O=C(NCC1=CC=C(OCC(F)(F)F)C=C1)C=2C=C(C(=NC2N)N)N3N=C(N=C3)C4(CC4)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Takaaki Horii, et al. Novel antimalarial agent containing heterocyclic compound. WO2021149692A1. WIPO. 2021-07-29.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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Antimalarial agent 67

Parasite アイソフォーム固有の製品をすべて表示

Acyltransferase アイソフォーム固有の製品をすべて表示