Apoptosis inducer 61
Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER+ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells.
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- 分子式: C16H12FN7
- 分子量:321.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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BIRC3 |
Apoptosis inducer 61 (1.56-200 μM; 48 h) potently inhibits the viability of MCF-7, MDA-MB-231 and HGC-27 cancer cells, with IC50 values of 5.61 μM, 8.18 μM and 5.68 μM, respectively; this compound exhibits selective toxicity toward cancer cells compared to non-malignant CCD-1072Sk cells[1].
Apoptosis inducer 61 (5.61 μM (MCF-7), 8.18 μM (MDA-MB-231); 48 h) induces apoptosis in MCF-7 and MDA-MB-231 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 breast cancer cells, MDA-MB-231 breast cancer cells
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Concentration:5.61 μM (MCF-7); 8.18 μM (MDA-MB-231)
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Incubation Time:48 h
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Result:Showed 12.35% apoptotic cells (8.73% early, 3.62% late) and 1.71% necrotic cells in MCF-7 cells.
Showed 9.78% apoptotic cells (5.54% early, 4.24% late) and 0.38% necrotic cells in MDA-MB-231 cells.
化学情報
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分子量 321.31
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分子式 C16H12FN7
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SMILES
FC1=CC=C(C=C1)C2=CN(N=N2)CC3=NN(C=C3)C4=NC=NC=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Apoptosis inducer 61 関連分類
HY-182002 関連分類
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