ASP9436
ASP9436 is an orally active and blood-brain barrier permeable PDE10A inhibitor with an IC50 of 8 nM against human PDE10A. ASP9436 attenuates locomotor activity in mouse hyperactivity models and ameliorates visual recognition memory impairment in neonatal mice. ASP9436 is applicable to research related to schizophrenia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1401807-89-3
- 分子式: C25H25Cl2N5O2
- 分子量:498.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
human PDE 10A 8 nM (IC50) |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice aged 5-
6 weeks, PCP (2.5 mg/10 mL/kg, sc))-induced hyper-locomotion; Three-day-old male ddY mice PCP (15 mg/kg)-induced hyper-locomotion[1] -
Dosage:1, 3, 10, 30 mg/kg;0.0001, 0.0003, 0.001, 0.003 mg/kg (Neonatal mouse)
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Administration:p.o., single administration
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Result:Attenuated locomotor activityn, with an ED50 of 7.0 mg/kg.
Improved visual-recognition memory impairment in neonatal PCP-treated mice by the oral administration at 0.001 and 0.003 mg/kg in a novel object
recognition test (NORT).
化学情報
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CAS 番号 1401807-89-3
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分子量 498.40
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分子式 C25H25Cl2N5O2
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SMILES
O=C1C=CC(C2=CN(C)N=C2COC3=CC=C(C4=CC=CC5=C4N=CN5C)C=C3)=CN1C.Cl.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ASP9436 関連分類
HY-120291 関連分類
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