Asterriquinone
Asterriquinone (ARQ), a Asterriquinone analog, is a Grb-2 binding inhibitor. Asterriquinone inhibits the Grb-2 binding activity to tyrosine phosphorylated EGFR, with an IC50 of 8.37 μM. Asterriquinone is a HIV1 reverse transcriptase inhibitor with a Ki of 2.3 μM. Asterriquinone also inhibits Grb-7 and PLC-γ binding activities..
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 60696-52-8
- 分子式: C32H30N2O4
- 分子量:506.59
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 60696-52-8
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分子量 506.59
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分子式 C32H30N2O4
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SMILES
O=C1C(O)=C(C2=CN(C(C)(C)C=C)C3=C2C=CC=C3)C(C(O)=C1C4=CN(C(C)(C)C=C)C5=C4C=CC=C5)=O
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別名
ARQ; Asterriquinone SU5504
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Structure Classification
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Initial Source
Aspergillus fungi
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Alvi KA, et al. Asterriquinones produced by Aspergillus candidus inhibit binding of the Grb-2 adapter to phosphorylated EGF receptor tyrosine kinase. J Antibiot (Tokyo). 1999 Mar;52(3):215-23. [Content Brief]
[2]. Ono K, et al. Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues. Biochem Biophys Res Commun. 1991 Jan 15;174(1):56-62. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Asterriquinone 関連分類
HY-N14349 関連分類
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