BION106
BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Blue: Idasanutlin ligand (HY-15676); Pink: DHFR-TS ligand (HY-153007); Black: Linker (HY-W021401)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3077918-44-3
- 分子式: C57H69Cl2F2N9O9
- 分子量:1133.12
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BION106 (10 μM, 30-240 min) rapidly and efficiently degrades the dihydrofolate reductase-thymidylate synthase, which indicates that it can quickly form a productive ternary complex and initiate the degradation processPlasmodium falciparum[1].
BION106 (0.4-50 μM, 4 h) significantly reduces the content of dihydrofolate reductase-thymidylate synthase in the Plasmodium falciparum in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3077918-44-3
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分子量 1133.12
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分子式 C57H69Cl2F2N9O9
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SMILES
N#C[C@@]1(C2=C(C=C(C=C2)Cl)F)[C@@H](C3=C(C(Cl)=CC=C3)F)[C@@H](N[C@H]1CC(C)(C)C)C(NC4=C(C=C(C=C4)C(NCCOCCOCCOCCNC(CCC5=C(C=CC=C5)OCCCOC6=C(N)N=C(N)N=C6CC)=O)=O)OC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BION106 関連分類
HY-178728 関連分類
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