Brogidirsen
Brogidirsen (NS 089; NCNP 02) is a dual-targeting antisense oligonucleotide capable of inducing AAexon skipping. Brogidirsen consists of two 12-mer phosphorodiamidate morpholino oligomers (PMOs) linked directly together. Through these PMOs, Brogidirsen targets regenerating muscle fibers, facilitating the reprogramming of cells that overexpress MYOD1 into the myogenic lineage. Brogidirsen is used in research related to Duchenne muscular dystrophy.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2409088-11-3
- 分子式: C280H440N119O105P23
- 分子量:7865.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
Target: Dystrophin Synthesis[1]
体外実験
Brogidirsen (1-10 μM; 72 h) induces dose-dependent exon 44 skipping and dystrophin protein expression in donor-derived MYOD1-UDCs, myotubes, and MYOD1-transduced fibroblasts from DMD patients amenable to exon 44 skipping[2].
Brogidirsen (1-10 μM) exhibits an EC50 of 7.12 μM for exon 44 skipping in healthy donor-derived MYOD1-UDCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:healthy donor-derived MYOD1-UDCs
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Concentration:10 μM
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Incubation Time:/
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Result:Increased exon 44 skipping expression.
化学情報
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CAS 番号 2409088-11-3
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分子量 7865.60
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分子式 C280H440N119O105P23
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SMILES
[Brogidirsen]
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別名
NS 089; NCNP 02
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配列
RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2′a→5′)(m5U-m5U-G-m5U-G-m5U-C-m5U-m5U-m5U-C-m5U-m5U-C-m5U-G-m5U-m5U-A-G-C-C-A-C)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)