Brogidirsen
Brogidirsen (NS 089; NCNP 02) is a a dual-targeting antisense oligonucleotide. Brogidirsen can induce dystrophin protein experession. Brogidirsen can be used for the research of Duchenne muscular dystrophy.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2409088-11-3
- 分子式: C280H440N119O105P23
- 分子量:7865.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
Target: Dystrophin Synthesis[1]
体外実験
Brogidirsen (1-10 μM; 72 h) induces dose-dependent exon 44 skipping and dystrophin protein expression in donor-derived MYOD1-UDCs, myotubes, and MYOD1-transduced fibroblasts from DMD patients amenable to exon 44 skipping[2].
Brogidirsen (1-10 μM) exhibits an EC50 of 7.12 μM for exon 44 skipping in healthy donor-derived MYOD1-UDCs[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:healthy donor-derived MYOD1-UDCs
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Concentration:10 μM
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Incubation Time:/
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Result:Increased exon 44 skipping expression.
化学情報
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CAS 番号 2409088-11-3
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分子量 7865.60
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分子式 C280H440N119O105P23
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SMILES
[Brogidirsen]
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別名
NS 089; NCNP 02
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配列
RNA, [P-deoxy-P-(dimethylamino)](2′,3′-dideoxy-2′,3′-imino-2′,3′-seco)(2′a→5′)(m5U-m5U-G-m5U-G-m5U-C-m5U-m5U-m5U-C-m5U-m5U-C-m5U-G-m5U-m5U-A-G-C-C-A-C)
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)