CDK2 degrader 8
CDK2 degrader 8 is a selective cyclin-dependent kinase 2 (CDK2) degrader. CDK2 degrader 8 can be used in studies related to CDK2 degradation and HR+ HER2- breast cancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3099145-52-2
- 分子式: C25H19ClF3N5O5
- 分子量:561.90
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
CDK2 |
体外実験
CDK2 degrader 8 (compound 1) induces CDK2 degradation in CDK2-HiBiT HEK293 cells after 24 h of treatment, with a Dmax of 64.8%. In the corresponding GSPT1 Live-cell HiBiT assay, the Dmax of GSPT1 is only 3.3%, demonstrating selectivity for CDK2 degradation[1].
CDK2 degrader 8 (1 μM; 60 min) exhibits a CLint of 46.6 μL/min/mg in the human liver microsome stability assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c nude mice, 6-8 weeks old, approximately 18-22 g[1]
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Dosage:100 mg/kg
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Administration:i.p.; once daily for 21 days
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Result:Inhibited tumor growth compared with the vehicle group.
Achieved 50% TGI at Day 21.
化学情報
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CAS 番号 3099145-52-2
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分子量 561.90
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分子式 C25H19ClF3N5O5
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SMILES
FC(F)(OC1=CC=C(C2=NN=C(O2)NC3(CC3)C4=CC(Cl)=C5CN(C(C5=C4)=O)C6CCC(NC6=O)=O)C=C1)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CDK2 degrader 8 関連分類
HY-178007 関連分類
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