CDK9-IN-36
CDK9-IN-36 (Compound T7) is a potent, selective and metabolically stable CDK9 inhibitor with an IC50 value of 1.2 nM. CDK9-IN-36 effectively suppresses cell proliferation, reduces colony formation, and induces apoptosis in Osimertinib (HY-15772)-resistant NSCLC cells by downregulating Mcl-1. CDK9-IN-36 also demonstrates antitumor efficacy in a tumor xenograft model.
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- 分子式: C30H33F2N5O4
- 分子量:565.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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CDK9 1.2 nM (IC50) |
化学情報
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分子量 565.61
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分子式 C30H33F2N5O4
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SMILES
FC1=C(C2=CC(OCCCCCCO3)=C(C=C2)F)N=C(NC4=CC=C(C(NC5CCN(C(C)=O)CC5)=O)C3=C4)N=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)