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製品番号: HY-N12151

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Chaparrinone

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC₅₀: 0.037 and 0.34 μg/mL respectively).

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CAS 番号: 22611-34-3
分子式: C₂₀H₂₆O₇
分子量:378.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Chaparrinone 構造式

CAS 番号: 22611-34-3

容量

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

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Cellular Effect

Cell Line	Type	Value	Description	References
BT-549	IC₅₀	0.8 μg/mL Compound: chaparrinone	Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Hep 3B2	IC₅₀	2.17 μM Compound: 4	Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	>50 μM Compound: 4	Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human adriamycin-resistant HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HepG2	IC₅₀	1.2 μM Compound: 4	Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells measured after 48 hrs by MTT assay	[PMID: 23290052]
HL-60	EC₅₀	2.4 μM Compound: 26	Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay Induction of cell differentiation in human HL60 cells assessed as superoxide anion production after 4 days by NBT reduction assay	[PMID: 11754601]
HL-60	IC₅₀	1.2 μM Compound: 26	Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter Antiproliferative activity against human HL60 cells assessed as inhibition of [3H]thymidine incorporation after 4 days by liquid scintillation counter	[PMID: 11754601]
HL-60	IC₅₀	5 μM Compound: 26	Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay Cytotoxicity against human HL60 cells assessed as loss of membrane integrity after 4 days by trypan blue exclusion assay	[PMID: 11754601]
K562	IC₅₀	1.8 μg/mL Compound: chaparrinone	Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay Cytotoxicity against human K562 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
KB	ED₅₀	0.025 μg/mL Compound: 2, NSC-288754	Cytotoxicity against human KB cells by NCI method Cytotoxicity against human KB cells by NCI method	[PMID: 6875576]
KB	IC₅₀	1.2 μg/mL Compound: chaparrinone	Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
P388	IC₅₀	0.92 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells after 3 days by MTT assay Cytotoxicity against mouse P388 cells after 3 days by MTT assay	[PMID: 9644063]
SK-OV-3	IC₅₀	0.5 μg/mL Compound: chaparrinone	Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay	[PMID: 8984156]
Vero	IC₅₀	1.5 μg/mL Compound: chaparrinone	Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay Cytotoxicity against african green monkey Vero cells after 2 to 7 days by neutral red assay	[PMID: 8984156]

化学情報

CAS 番号 22611-34-3
分子量 378.42
分子式 C₂₀H₂₆O₇
SMILES

C[C@@]12[C@]3([H])[C@@]45[C@@](OC(C[C@@]4([H])[C@H]([C@H]([C@@]3(OC5)O)O)C)=O)([H])C[C@@]1([H])C(C)=CC([C@H]2O)=O
Structure Classification
- Others
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [Content Brief]

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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生物活性
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化学情報
純度とドキュメンテーション
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Chaparrinone

Parasite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Chaparrinone 関連分類

HY-N12151 関連分類